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Complete genome sequence of Treponema pallidum strain DAL-1
M. Zobaníková, P. Mikolka, D. Cejková, P. Pospíšilová, L. Chen, M. Strouhal, X. Qin, GM. Weinstock, D. Smajs
Language English Country United States
Document type Journal Article
Grant support
NT11159
MZ0
CEP Register
Digital library NLK
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PubMed
23449808
DOI
10.4056/sigs.2615838
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
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