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Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio
E. Praskova, D. Zivna, S. Stepanova, M. Sevcikova, J. Blahova, P. Marsalek, Z. Siroka, E. Voslarova, Z. Svobodova,
Jazyk angličtina Země Švédsko
Typ dokumentu časopisecké články
- MeSH
- antiflogistika nesteroidní toxicita MeSH
- Aspirin toxicita MeSH
- chemické látky znečišťující vodu toxicita MeSH
- dánio pruhované embryologie MeSH
- embryo nesavčí účinky léků MeSH
- kvalita vody MeSH
- LD50 MeSH
- metabolická inaktivace fyziologie MeSH
- oxidační stres účinky léků fyziologie MeSH
- testy akutní toxicity MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme. METHODS: Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology. RESULTS: The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid. CONCLUSIONS: The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish.
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- $a Praskova, Eva $u Department of Veterinary Public Health and Toxicology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic. epraskova@vfu.cz
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- $a Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio / $c E. Praskova, D. Zivna, S. Stepanova, M. Sevcikova, J. Blahova, P. Marsalek, Z. Siroka, E. Voslarova, Z. Svobodova,
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- $a OBJECTIVES: The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme. METHODS: Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology. RESULTS: The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid. CONCLUSIONS: The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish.
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