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The association between levels of tissue inhibitor of metalloproteinase-1 with acute heart failure and left ventricular dysfunction in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention
Monika Pavkova Goldbergova, Jiri Parenica, Jiri Jarkovsky, Petr Kala, Martin Poloczek, Jan Manousek, Krystyna Kluz, Lenka Kubkova, Simona Littnerova, Martin Tesak, Ondrej Toman, Nikolas Pavek, Zdenka Cermakova, Josef Tomandl, Anna Vasku, Jindrich Spinar
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NS9894
MZ0
CEP - Centrální evidence projektů
PubMed
22971139
DOI
10.1089/gtmb.2012.0120
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- dysfunkce levé srdeční komory krev genetika MeSH
- infarkt myokardu krev genetika terapie MeSH
- koronární angioplastika metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- senioři MeSH
- srdeční selhání krev genetika MeSH
- tkáňový inhibitor metaloproteinasy 1 krev genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
AIMS: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. METHODS: In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24 h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. RESULTS: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented. CONCLUSION: These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
Biochemistry Department University Hospital Brno Brno Czech Republic
Cardiology Department Hospital Podlesi a s Třinec Czech Republic
Institute of Biochemistry Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
Institute of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Pathological Physiology Masaryk University Brno Czech Republic
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- $a The association between levels of tissue inhibitor of metalloproteinase-1 with acute heart failure and left ventricular dysfunction in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention / $c Monika Pavkova Goldbergova, Jiri Parenica, Jiri Jarkovsky, Petr Kala, Martin Poloczek, Jan Manousek, Krystyna Kluz, Lenka Kubkova, Simona Littnerova, Martin Tesak, Ondrej Toman, Nikolas Pavek, Zdenka Cermakova, Josef Tomandl, Anna Vasku, Jindrich Spinar
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- $a AIMS: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. METHODS: In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24 h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. RESULTS: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented. CONCLUSION: These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
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