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Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress
AV. Komina, KA. Korostileva, SN. Gyrylova, RN. Belonogov, TG. Ruksha
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Alleles MeSH
- Adult MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide * MeSH
- Catalase genetics metabolism MeSH
- Leukocytes, Mononuclear metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Mutation MeSH
- Oxidative Stress * MeSH
- Reactive Oxygen Species metabolism MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H(2)O(2)-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H(2)O(2). Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.
References provided by Crossref.org
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