Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress

AV. Komina, KA. Korostileva, SN. Gyrylova, RN. Belonogov, TG. Ruksha

. 2012 ; 61 (6) : 655-658.

Language English Country Czech Republic

Document type Journal Article

Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H(2)O(2)-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H(2)O(2). Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13033350
003      
CZ-PrNML
005      
20131025121314.0
007      
ta
008      
131015s2012 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932333 $2 doi
035    __
$a (PubMed)23098659
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Komina, A. V. $u Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia
245    10
$a Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress / $c AV. Komina, KA. Korostileva, SN. Gyrylova, RN. Belonogov, TG. Ruksha
520    9_
$a Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The -262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H(2)O(2)-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H(2)O(2). Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress.
650    _2
$a dospělí $7 D000328
650    _2
$a alely $7 D000483
650    _2
$a katalasa $x genetika $x metabolismus $7 D002374
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genotyp $7 D005838
650    _2
$a lidé $7 D006801
650    _2
$a leukocyty mononukleární $x metabolismus $7 D007963
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a mutace $7 D009154
650    12
$a oxidační stres $7 D018384
650    12
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a reaktivní formy kyslíku $x metabolismus $7 D017382
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Korostileva, K. A. $u Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia
700    1_
$a Gyrylova, S. N. $u Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia
700    1_
$a Belonogov, R. N. $u Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia
700    1_
$a Ruksha, T. G. $u Department of Pathophysiology, Krasnoyarsk State Medical University Named After V. F. Voino-Yasenetsky, Russian Federation Ministry for Health and Social Development, Krasnoyarsk, Russia
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 61, č. 6 (2012), s. 655-658
856    41
$u http://www.biomed.cas.cz/physiolres/archive.htm $y domovská stránka časopisu - plný text volně přístupný = fulltext
910    __
$a ABA008 $b A 4120 $c 266 $y 3 $z 0
990    __
$a 20131015 $b ABA008
991    __
$a 20131025105756 $b ABA008
999    __
$a ok $b bmc $g 998656 $s 831804
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 61 $c 6 $d 655-658 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK111 $a Pubmed-20131015

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...