Papilomavírusy patria medzi vírusy s dvojvláknovou DNA (dsDNA). Sú schopné navodiť tak tvorbu benígnych, ako aj malígnych nádorov. Spojitosť medzi infekciou ľudskými papilomavírusmi (HPV) a rakovinou krčka maternice bola detailne opísaná len nedávno vďaka profesorovi zur Hausenovi. Avšak existujú zástupcovia HPV vírusov, u ktorých nebola dokázaná asociácia s vytváraním malignít. Preto rozoznávame tzv. vysoko-(HR) a nízkorizikové (LR) typy papilómov. V našej práci opisujeme životný cyklus HPV, molekulárne mechanizmy počas onkogenézy a snažíme sa o porovnanie HR HPV a LR HPV.

Papillomaviruses belong to a group of viruses with double-stranded DNA (dsDNA). These viruses are believed to induce benign as well as malignant tumour growth. Thanks to professor zur Hausen, the connection between the infection by human papillomaviruses (HPV) and cervix cancer was described in detail a few years ago. However, there exist certain types of HPV viruses, in which no association with malignancies was ever demonstrated. Hence, we can divide HPV into „high-risk“ (HR) and „low-risk“ (LR) group. Our work describes the life cycle of HPV, molecular mechanisms of oncogenesis and aims to compare HR HPV and LR HPV within these terms. Key words: viral cell transformation – oncogene protein E6 – oncogene protein E7 – E5 protein HPV-16 – „high-risk“ – „low-risk“ The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers. Submitted: 28. 6. 2013 Accepted: 14. 7. 2013

Katedra mikrobiológie a virológie PRIF UK Bratislava

Oncogenic potential of papillomaviruses

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