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Alkaloid chelirubine and DNA: blue and red luminescence
M. Rajecky, I. Slaninova, P. Mokrisova, J. Urbanova, M. Palkovsky, E. Taborska, P. Taborsky,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- alkaloidy chemie MeSH
- DNA chemie MeSH
- luminiscence MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Extracts from Himalayan herb Dicranostigma lactucoides containing alkaloid chelirubine have been used for centuries in Chinese herbal medicine. We have found a new utilization for the alkaloid: it can be used as a DNA fluorescent probe showing blue (free form) and red (intercalated to DNA) luminescence emission after irradiation by near-UV light. Besides quantification of DNA (LOD = 6 ng ml(-1)) it can also be used as a supravital cell probe because chelirubine molecules can effectively enter into the living cell through the cell membrane.
Citace poskytuje Crossref.org
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