Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses

T Tsuchiya, PE Schwarz, LD Bosque-Plata, Hayes M Geoffrey, C Dina, P Froguel, Towers G Wayne, S Fischer, T Temelkova-Kurktschiev, H Rietzsch, J Graessler, J Vcelak, D Palyzova, T Selisko, B Bendlova, J Schulze, U Julius, M Hanefeld, MN Weedon, JC...

. 2006 ; 89 (1-2) : 174-184.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu metaanalýza, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc14048345

Grantová podpora
NR7809 MZ0 CEP - Centrální evidence projektů

We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.

000      
00000naa a2200000 a 4500
001      
bmc14048345
003      
CZ-PrNML
005      
20140313124557.0
007      
ta
008      
140307s2006 xxu f 000 0|eng||
009      
AR
035    __
$a (PubMed)16837224
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Tsuchiya, Takafumi $u Departments of Medicine and Human Genetics, The University of Chicago, 5841 S. Maryland Ave., MC1027, Chicago, IL 60637, USA.
245    10
$a Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses / $c T Tsuchiya, PE Schwarz, LD Bosque-Plata, Hayes M Geoffrey, C Dina, P Froguel, Towers G Wayne, S Fischer, T Temelkova-Kurktschiev, H Rietzsch, J Graessler, J Vcelak, D Palyzova, T Selisko, B Bendlova, J Schulze, U Julius, M Hanefeld, MN Weedon, JC Evans, TM Frayling, AT Hattersley, M Orho-Melander, L Groop, MT Malecki, T Hansen, O Pedersen, TE Fingerlin, M Boehnke, CL Hanis, NJ Cox, GI Bell
520    9_
$a We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.
536    __
$c Grant Number: DK-20595 (United States NIDDK NIH HHS)
536    __
$c Grant Number: DK-47486 (United States NIDDK NIH HHS)
536    __
$c Grant Number: DK-47487 (United States NIDDK NIH HHS)
536    __
$c Grant Number: DK-55889 (United States NIDDK NIH HHS)
590    __
$a bohemika - dle Pubmed
650    12
$a kalpain $x genetika $7 D002154
650    12
$a diabetes mellitus 2. typu $x genetika $7 D003924
650    12
$a běloši $x genetika $7 D044465
650    02
$a haplotypy $x genetika $7 D006239
650    02
$a lidé $7 D006801
650    12
$a vazebná nerovnováha $7 D015810
650    12
$a jednonukleotidový polymorfismus $7 D020641
655    _2
$a metaanalýza $7 D017418
655    _2
$a multicentrická studie $7 D016448
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Schwarz, Peter E.
700    1_
$a Bosque-Plata, Laura del
700    1_
$a Geoffrey Hayes, M.
700    1_
$a Dina, Chrisitan
700    1_
$a Froguel, Philippe
700    1_
$a Wayne Towers, G.
700    1_
$a Fischer, Sabine
700    1_
$a Temelkova-Kurktschiev, Theodora
700    1_
$a Rietzsch, Hannes
700    1_
$a Graessler, Juergen
700    1_
$a Včelák, Josef, $d 1971- $7 xx0107261 $u Institute of Endocrinology, Prague, Czech Republic
700    1_
$a Palyzová, Daniela, $d 1941- $7 skuk0004445 $u Clinic of Children and Adolescents and 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Selisko, Thomas
700    1_
$a Bendlová, Běla, $d 1962- $7 jo20000074069 $u Institute of Endocrinology, Prague, Czech Republic
700    1_
$a Schulze, Jan
700    1_
$a Julius, Ulrich
700    1_
$a Hanefeld, Markolf
700    1_
$a Weedon, Michael N.
700    1_
$a Evans, Julie C.
700    1_
$a Frayling, Timothy M.
700    1_
$a Hattersley, Andrew T.
700    1_
$a Orho-Melander, Marju
700    1_
$a Groop, Leif
700    1_
$a Malecki, Maciej T.
700    1_
$a Hansen, Torben
700    1_
$a Pedersen, Oluf
700    1_
$a Fingerlin, Tasha E.
700    1_
$a Boehnke, Michael
700    1_
$a Hanis, Craig L.
700    1_
$a Cox, Nancy J.
700    1_
$a Bell, Graeme I.
773    0_
$t Molecular genetics and metabolism $x 1096-7192 $g Roč. 89, č. 1-2 (2006), s. 174-184 $p Mol Genet Metab $w MED00006573
910    __
$a ABA008 $y 4 $z 0
990    __
$a 20140307150641 $b ABA008
991    __
$a 20140313124607 $b ABA008
999    __
$a ok $b bmc $g 1015446 $s 846900
BAS    __
$a 3
BMC    __
$a 2006 $b 89 $c 1-2 $d 174-184 $x MED00006573 $i 1096-7192 $m Molecular genetics and metabolism $n Mol Genet Metab
GRA    __
$a NR7809 $p MZ0
LZP    __
$a NLK 2014-03/lpbo
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace