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In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb
P. Landa, L. Skalova, I. Bousova, Z. Kutil, L. Langhansova, JD. Lou, T. Vanek,
Language English Country Pakistan
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24374437
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents pharmacology MeSH
- Antineoplastic Agents, Phytogenic pharmacology MeSH
- Humans MeSH
- Plant Leaves MeSH
- Cell Line, Tumor MeSH
- Fruit MeSH
- Cell Proliferation drug effects MeSH
- Plant Extracts pharmacology MeSH
- Vaccinium * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 μg/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 μg/mL, respectively. These results indicate that V. bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.
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