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Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis
Z. Zemanova, K. Michalova, H. Buryova, J. Brezinova, K. Kostylkova, D. Bystricka, M. Novakova, I. Sarova, S. Izakova, L. Lizcova, S. Ransdorfova, Z. Krejcik, MD. Merkerova, A. Dohnalova, M. Siskova, A. Jonasova, R. Neuwirtova, J. Cermak,
Leukemia research.
2014 ;
38 (5) :
537-44.
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc14063686
- MeSH
- Chromosome Deletion * MeSH
- Adult MeSH
- Karyotype MeSH
- Middle Aged MeSH
- Humans MeSH
- Chromosomes, Human, Pair 5 * MeSH
- Myelodysplastic Syndromes genetics mortality MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Comparative Genomic Hybridization MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months).
Institute of Hematology and Blood Transfusion Prague Czech Republic
Institute of Physiology 1st Faculty of Medicine Charles University Prague Czech Republic
References provided by Crossref.org
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