Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission. The second objective was to determine optimal cut-off value and quantify diagnostic characteristics of TFF2 between controls and patients with various septic states. The study included 57 children aged 0-19 years, with expected or proven SIRS and septic condition. The degree of severity was evaluated according to PELOD Score (Pediatric Logistic Organ Dysfunction). Blood samples to determine levels of TFF2 factor were taken during the time patient met the criteria of SIRS or sepsis. Control group samples to determine the serum levels of TFF2 were taken from patients undergoing elective surgery. Analysis of TFF2 levels dynamics revealed that TFF2 levels kept steady state during the 5-day period. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome (MODS). The difference was noticed also in ROC analysis.

Department of Anesthesia and Intensive Care University Children's Hospital Černopolní 9 Brno 62500 Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc14064188

003      

CZ-PrNML

005      

20180110151224.0

007      

ta

008      

140704s2013 xxu f 000 0|eng||

009      

AR

024    7_

$a 10.1016/j.peptides.2013.04.011 $2 doi

035    __

$a (PubMed)23628371

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xxu

100    1_

$a Zurek, Jiří $u Department of Anesthesia and Intensive Care, University Children's Hospital, Černopolní 9, Brno 62500, Czech Republic. jzurek@fnbrno.cz

245    10

$a Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children / $c J. Zurek, M. Kýr, M. Vavřina, M. Fedora,

520    9_

$a Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission. The second objective was to determine optimal cut-off value and quantify diagnostic characteristics of TFF2 between controls and patients with various septic states. The study included 57 children aged 0-19 years, with expected or proven SIRS and septic condition. The degree of severity was evaluated according to PELOD Score (Pediatric Logistic Organ Dysfunction). Blood samples to determine levels of TFF2 factor were taken during the time patient met the criteria of SIRS or sepsis. Control group samples to determine the serum levels of TFF2 were taken from patients undergoing elective surgery. Analysis of TFF2 levels dynamics revealed that TFF2 levels kept steady state during the 5-day period. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome (MODS). The difference was noticed also in ROC analysis.

650    _2

$a mladiství $7 D000293

650    _2

$a dítě $7 D002648

650    _2

$a předškolní dítě $7 D002675

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a žaludeční sliznice $x cytologie $x metabolismus $7 D005753

650    _2

$a lidé $7 D006801

650    _2

$a kojenec $7 D007223

650    _2

$a střeva $x zranění $x metabolismus $7 D007422

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a multiorgánové selhání $x krev $x metabolismus $7 D009102

650    _2

$a peptidy $x krev $x metabolismus $7 D010455

650    _2

$a ROC křivka $7 D012372

650    _2

$a sepse $x krev $x diagnóza $x metabolismus $7 D018805

650    _2

$a syndrom systémové zánětlivé reakce $x krev $x metabolismus $x chirurgie $7 D018746

655    _2

$a časopisecké články $7 D016428

700    1_

$a Kýr, Michal

700    1_

$a Vavřina, Martin $7 xx0220124

700    1_

$a Fedora, Michal

773    0_

$w MED00003749 $t Peptides $x 1873-5169 $g Roč. 46, č. - (2013), s. 1-5

856    41

$u https://pubmed.ncbi.nlm.nih.gov/23628371 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y a $z 0

990    __

$a 20140704 $b ABA008

991    __

$a 20180110151450 $b ABA008

999    __

$a ok $b bmc $g 1031672 $s 862920

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2013 $b 46 $c - $d 1-5 $i 1873-5169 $m Peptides $n Peptides $x MED00003749

LZP    __

$a Pubmed-20140704