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Analytical model of chemical phase and formation of DSB in chromosomes by ionizing radiation
J. Barilla, M. Lokajíček, H. Pisaková, P. Simr,
Language English Country Netherlands
Document type Journal Article
NLK
ProQuest Central
from 2005-03-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2008-06-01 to 2019-12-31
Health & Medicine (ProQuest)
from 2005-03-01 to 1 year ago
- MeSH
- Bacteriophage phi X 174 genetics radiation effects MeSH
- Models, Biological * MeSH
- Chromosomes drug effects radiation effects MeSH
- Diffusion drug effects radiation effects MeSH
- DNA Breaks, Double-Stranded drug effects radiation effects MeSH
- Radiation, Ionizing * MeSH
- Oxygen pharmacology MeSH
- Publication type
- Journal Article MeSH
Mathematical analytical model of the processes running in individual radical clusters during the chemical phase (under the presence of radiomodifiers) proposed by us earlier has been further developed and improved. It has been applied to the data presented by Blok and Loman characterizing the oxygen effect in SSB and DSB formation (in water solution and at low-LET radiation) also in the region of very small oxygen concentrations, which cannot be studied with the help of experiments done with living cells. In this new analysis the values of all reaction rates and diffusion parameters known from literature have been made use of. The great increase of SSB and DSB at zero oxygen concentration may follow from the fact that at small oxygen concentrations the oxygen absorbs other radicals while at higher concentrations the formation of oxygen radicals prevails. It explains the double oxygen effect found already earlier by Ewing. The model may be easily extended to include also the effects of other radiomodifiers present in medium during irradiation.
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