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Antioxidant/oxidant status and cardiac function in bradykinin B(1)- and B(2)-receptor null mice
S. Delemasure, N. Blaes, C. Richard, R. Couture, M. Bader, P. Dutartre, JP. Girolami, JL. Connat, L. Rochette
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- Antioxidants metabolism MeSH
- Biomarkers blood MeSH
- Ventricular Dysfunction, Left blood genetics metabolism physiopathology MeSH
- Ventricular Function, Left * MeSH
- Myocardial Contraction * MeSH
- Dehydroascorbic Acid analogs & derivatives blood MeSH
- Myocardium metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice, 129 Strain MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Oxidative Stress * MeSH
- Echocardiography, Doppler, Pulsed MeSH
- Receptor, Bradykinin B1 deficiency genetics MeSH
- Receptor, Bradykinin B2 deficiency genetics MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Kinin-vasoactive peptides activate two G-protein-coupled receptors (R), B(1)R (inducible) and B(2)R (constitutive). Their complex role in cardiovascular diseases could be related to differential actions on oxidative stress. This study investigated impacts of B(1)R or B(2)R gene deletion in mice on the cardiac function and plasma antioxidant and oxidant status. Echocardiography-Doppler was performed in B(1)R (B(1)R(-/-)) and B(2)R (B(2)R(-/-)) deficient and wild type (WT) adult male mice. No functional alteration was observed in B(2)R(-/-) hearts. B(1)R(-/-) mice had significantly lowered fractional shortening and increased isovolumetric contraction time. The diastolic E and A waves velocity ratio was similar in all mice groups. Thus B(1)R(-/-) mice provide a model of moderate systolic dysfunction, whereas B(2)R(-/-) mice displayed a normal cardiac phenotype. Plasma antioxidant capacity (ORAC) was significantly decreased in both B(1)R(-/-) and B(2)R(-/-) mice whereas the vitamin C levels were decreased in B(2)R(-/-) mice only. Plasma ascorbyl free radical was significantly higher in B(1)R(-/-) compared to WT and B(2)R(-/-) mice. Therefore, the oxidative stress index, ascorbyl free radical to vitamin C ratio, was increased in both B(1)R(-/-) and B(2)R(-/-) mice. Hence, B(1)R and B(2)R deficiency are associated with increased oxidative stress, but there is a differential imbalance between free radical production and antioxidant defense. The interrelationship between the differential B(1)R and B(2)R roles in oxidative stress and cardiovascular diseases remain to be investigated.
COHIRO Biotechnology Faculty of Medicine Dijon France
Department of Physiology Faculty of Medicine Université de Montréal Montréal Qc Canada
References provided by Crossref.org
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