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Prevalence of perfusion defects detected by stress 99mtechnetium sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with breast cancer

B. Melichar, J. Doležal, V. Srámek, H. Kalábová, LK. Krčmová, R. Hyšpler, H. Studentová, M. Vošmik, M. Pecka, A. Svobodník, L. Pecen, M. Doležel, D. Solichová,

. 2014 ; 34 (7) : 3689-3694.

Language English Country Greece

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc14074136

Grant support
NT13564 MZ0 CEP Register

AIM: The aim of the present study was to investigate myocardial perfusion in relation to disease history and laboratory parameters of atherosclerosis risk in asymptomatic patients with breast carcinoma. PATIENTS AND METHODS: One-hundred and eighty-one patients with breast carcinoma were studied. Myocardial perfusion was assessed using single-photon emission computed tomography (SPECT) with 99mtechnetium sestamibi. RESULTS: Perfusion defects were detected in 12 patients (7%). Higher body-mass index, increased concentrations of D-dimers, C-reactive protein, fibrinogen, glucose, triglycerides, and urinary albumin, a history of hypertension and of radiotherapy to the left chest wall were all associated with increased risk of perfusion defects. In a multivariate stepwise selection logistic regression model, body mass index, albuminuria and radiotherapy to the left hemithorax were significantly associated with the presence of perfusion defects. CONCLUSION: In addition to other factors, treatment history may be associated with the presence of perfusion defects in patients with breast cancer.

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$a Melichar, Bohuslav, $u Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; Fourth Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; $d 1965- $7 skuk0000853
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$a Prevalence of perfusion defects detected by stress 99mtechnetium sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with breast cancer / $c B. Melichar, J. Doležal, V. Srámek, H. Kalábová, LK. Krčmová, R. Hyšpler, H. Studentová, M. Vošmik, M. Pecka, A. Svobodník, L. Pecen, M. Doležel, D. Solichová,
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$a AIM: The aim of the present study was to investigate myocardial perfusion in relation to disease history and laboratory parameters of atherosclerosis risk in asymptomatic patients with breast carcinoma. PATIENTS AND METHODS: One-hundred and eighty-one patients with breast carcinoma were studied. Myocardial perfusion was assessed using single-photon emission computed tomography (SPECT) with 99mtechnetium sestamibi. RESULTS: Perfusion defects were detected in 12 patients (7%). Higher body-mass index, increased concentrations of D-dimers, C-reactive protein, fibrinogen, glucose, triglycerides, and urinary albumin, a history of hypertension and of radiotherapy to the left chest wall were all associated with increased risk of perfusion defects. In a multivariate stepwise selection logistic regression model, body mass index, albuminuria and radiotherapy to the left hemithorax were significantly associated with the presence of perfusion defects. CONCLUSION: In addition to other factors, treatment history may be associated with the presence of perfusion defects in patients with breast cancer.
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$a Doležal, Jiří, $u Department of Nuclear Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; $d 1969- $7 xx0052087
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$a Šrámek, Vlastislav $u Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic. $7 xx0246106
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$a Doležel, Martin $u Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic dolezelm@email.cz.
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$a Solichová, Dagmar $u Department of Nuclear Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; $7 xx0060526
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