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Copper: effects of deficiency and overload
I. Scheiber, R. Dringen, JF. Mercer,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Ion Transport MeSH
- Copper * adverse effects deficiency metabolism MeSH
- Neurodegenerative Diseases * chemically induced metabolism pathology MeSH
- Reactive Oxygen Species metabolism MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Copper is an essential trace metal that is required for the catalysis of several important cellular enzymes. However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. This chapter summarizes the current knowledge on the importance of copper for cellular processes and on the mechanisms involved in cellular copper uptake, storage and export. In addition, we will give an overview on disturbances of copper homeostasis that are characterized by copper overload or copper deficiency or have been connected with neurodegenerative disorders.
References provided by Crossref.org
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