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Urine microRNAs as potential noninvasive biomarkers in urologic cancers
H. Mlcochova, R. Hezova, M. Stanik, O. Slaby,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
NT13547
MZ0
CEP Register
- MeSH
- Humans MeSH
- MicroRNAs genetics urine MeSH
- Biomarkers, Tumor genetics urine MeSH
- Kidney Neoplasms diagnosis genetics urine MeSH
- Urinary Bladder Neoplasms diagnosis genetics urine MeSH
- Prostatic Neoplasms diagnosis genetics urine MeSH
- Prognosis MeSH
- Sensitivity and Specificity MeSH
- Urologic Neoplasms diagnosis genetics urine MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.
Central European Institute of Technology Masaryk University Brno Czech Republic
Masaryk Memorial Cancer Institute Department of Urologic Oncology Brno Czech Republic
References provided by Crossref.org
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