Urine microRNAs as potential noninvasive biomarkers in urologic cancers
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24035473
DOI
10.1016/j.urolonc.2013.04.011
PII: S1078-1439(13)00197-X
Knihovny.cz E-resources
- Keywords
- Biomarker, Bladder cancer, Diagnosis, MicroRNA, Prostate cancer, Renal cell carcinoma, Urologic cancer, Urothelial cancer,
- MeSH
- Humans MeSH
- MicroRNAs genetics urine MeSH
- Biomarkers, Tumor genetics urine MeSH
- Kidney Neoplasms diagnosis genetics urine MeSH
- Urinary Bladder Neoplasms diagnosis genetics urine MeSH
- Prostatic Neoplasms diagnosis genetics urine MeSH
- Prognosis MeSH
- Sensitivity and Specificity MeSH
- Urologic Neoplasms diagnosis genetics urine MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- MicroRNAs MeSH
- Biomarkers, Tumor MeSH
Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.
References provided by Crossref.org
Urinary microRNAs and Their Significance in Prostate Cancer Diagnosis: A 5-Year Update
MicroRNAs in urine are not biomarkers of multiple myeloma
