Urine microRNAs as potential noninvasive biomarkers in urologic cancers
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
24035473
DOI
10.1016/j.urolonc.2013.04.011
PII: S1078-1439(13)00197-X
Knihovny.cz E-zdroje
- Klíčová slova
- Biomarker, Bladder cancer, Diagnosis, MicroRNA, Prostate cancer, Renal cell carcinoma, Urologic cancer, Urothelial cancer,
- MeSH
- lidé MeSH
- mikro RNA genetika moč MeSH
- nádorové biomarkery genetika moč MeSH
- nádory ledvin diagnóza genetika moč MeSH
- nádory močového měchýře diagnóza genetika moč MeSH
- nádory prostaty diagnóza genetika moč MeSH
- prognóza MeSH
- senzitivita a specificita MeSH
- urologické nádory diagnóza genetika moč MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- mikro RNA MeSH
- nádorové biomarkery MeSH
Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.
Citace poskytuje Crossref.org
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