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The DNA-damage response in human biology and disease
SP Jackson, J Bartek
Jazyk angličtina Země Anglie, Velká Británie
NLK
Nature Journals Online
od 1997
Nature Journal Archive
od 1997
ProQuest Central
od 1988-01-07 do Před 1 rokem
Medline Complete (EBSCOhost)
od 1997-06-05 do 2015-11-19
Nursing & Allied Health Database (ProQuest)
od 1988-01-07 do Před 1 rokem
Health & Medicine (ProQuest)
od 1988-01-07 do Před 1 rokem
Psychology Database (ProQuest)
od 1988-01-07 do Před 1 rokem
Public Health Database (ProQuest)
od 1988-01-07 do Před 1 rokem
PubMed
19847258
DOI
10.1038/nature08467
Knihovny.cz E-zdroje
- MeSH
- buněčný cyklus fyziologie MeSH
- genom lidský genetika MeSH
- lidé MeSH
- nemoc * MeSH
- oprava DNA * genetika fyziologie MeSH
- poškození DNA * genetika fyziologie MeSH
- signální transdukce MeSH
- Check Tag
- lidé MeSH
The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.
Citace poskytuje Crossref.org
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