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The DNA-damage response in human biology and disease
SP Jackson, J Bartek
Language English Country England, Great Britain
NLK
Nature Journals Online
from 1997
Nature Journal Archive
from 1997
ProQuest Central
from 1988-01-07 to 1 year ago
Medline Complete (EBSCOhost)
from 1997-06-05 to 2015-11-19
Nursing & Allied Health Database (ProQuest)
from 1988-01-07 to 1 year ago
Health & Medicine (ProQuest)
from 1988-01-07 to 1 year ago
Psychology Database (ProQuest)
from 1988-01-07 to 1 year ago
Public Health Database (ProQuest)
from 1988-01-07 to 1 year ago
PubMed
19847258
DOI
10.1038/nature08467
Knihovny.cz E-resources
- MeSH
- Cell Cycle physiology MeSH
- Genome, Human genetics MeSH
- Humans MeSH
- Disease * MeSH
- DNA Repair * genetics physiology MeSH
- DNA Damage * genetics physiology MeSH
- Signal Transduction MeSH
- Check Tag
- Humans MeSH
The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.
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- $a The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.
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- $c Grant Number: (United Kingdom Biotechnology and Biological Sciences Research Council)
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- $c Grant Number: (United Kingdom Cancer Research UK)
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- $c Grant Number: (United Kingdom Wellcome Trust)
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