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Anorexigenní neuropeptid CART v regulaci příjmu potravy
[Anorexigenic neuropeptide CART in food intake regulation]
Veronika Nagelová, Blanka Železná, Lenka Maletínská
Chemické listy.
2014 ;
108 (4) :
354-357.
Language Czech Country Czech Republic
Document type Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc14078824
- Keywords
- cocaine- and amphetamine-regulated transcript,
- MeSH
- Cholecystokinin physiology MeSH
- Energy Metabolism drug effects MeSH
- Pharmacy methods trends MeSH
- Transcription, Genetic MeSH
- Homeostasis drug effects MeSH
- Anti-Obesity Agents pharmacology chemistry therapeutic use MeSH
- Leptin physiology MeSH
- Humans MeSH
- Neurons physiology MeSH
- Neuropeptides pharmacokinetics pharmacology genetics chemistry MeSH
- Obesity * prevention & control MeSH
- Eating drug effects MeSH
- Nerve Tissue Proteins chemistry MeSH
- Appetite Regulation * drug effects MeSH
- Research MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
The cocaine- and amphetamine-regulated transcript (CART) peptide is a brain-born and brain-acting neuropeptide with anorexigenic properties. Production of the CART peptide in the brain is regulated by the anorexigenic hormone leptin. The CART peptide acts synergistically with the anorexigenic gut hormone cholecystokinin in attenuating food intake and neuron activation. A compact structure of the CART peptide with three disulfide bridges does not permit to make the biologically active molecule shorter; only one disulfide bridge can be omitted without losing biological activity. So far the CART peptide receptor has not been identified.
Anorexigenic neuropeptide CART in food intake regulation
Bibliography, etc.
Literatura
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