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Mammalian G1- and S-phase checkpoints in response to DNA damage
J Bartek, J Lukas
Language English Country United States
PubMed
11698191
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- cdc25 Phosphatases physiology MeSH
- G1 Phase * MeSH
- Tumor Suppressor Protein p53 physiology MeSH
- Neoplasms genetics MeSH
- DNA Damage * MeSH
- Forecasting MeSH
- Protein Kinases physiology MeSH
- S Phase * MeSH
- Transcription Factors physiology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
The ability to preserve genomic integrity is a fundamental feature of life. Recent findings regarding the molecular basis of the cell-cycle checkpoint responses of mammalian cells to genotoxic stress have converged into a two-wave concept of the G1 checkpoint, and shed light on the so-far elusive intra-S-phase checkpoint. Rapidly operating cascades that target the Cdc25A phosphatase appear central in both the initiation wave of the G1 checkpoint (preceding the p53-mediated maintenance wave) and the transient intra-S-phase response. Multiple links between defects in the G1/S checkpoints, genomic instability and oncogenesis are emerging, as are new challenges and hopes raised by this knowledge.
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- $a The ability to preserve genomic integrity is a fundamental feature of life. Recent findings regarding the molecular basis of the cell-cycle checkpoint responses of mammalian cells to genotoxic stress have converged into a two-wave concept of the G1 checkpoint, and shed light on the so-far elusive intra-S-phase checkpoint. Rapidly operating cascades that target the Cdc25A phosphatase appear central in both the initiation wave of the G1 checkpoint (preceding the p53-mediated maintenance wave) and the transient intra-S-phase response. Multiple links between defects in the G1/S checkpoints, genomic instability and oncogenesis are emerging, as are new challenges and hopes raised by this knowledge.
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