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CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis
L. Peng, A. Skylar, PL. Chang, K. Bisova, X. Wu,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
- MeSH
- Transcriptional Activation MeSH
- Arabidopsis embryology MeSH
- Cell Division genetics MeSH
- Cyclin-Dependent Kinases biosynthesis MeSH
- Cyclins biosynthesis genetics metabolism MeSH
- Homeodomain Proteins genetics MeSH
- Meristem cytology embryology MeSH
- Cell Proliferation MeSH
- Arabidopsis Proteins biosynthesis genetics metabolism MeSH
- Gene Expression Regulation, Plant MeSH
- Genes, Plant MeSH
- Sucrose pharmacology MeSH
- Seedlings genetics MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
In higher plants, cell cycle activation in the meristems at germination is essential for the initiation of post-embryonic development. We previously identified the signaling pathways of homeobox transcription factor STIMPY and metabolic sugars as two interacting branches of the regulatory network that is responsible for activating meristematic tissue proliferation in Arabidopsis. In this study, we found that CYCP2;1 is both a direct target of STIMPY transcriptional activation and an early responder to sugar signals. Genetic and molecular studies show that CYCP2;1 physically interacts with three of the five mitotic CDKs in Arabidopsis, and is required for the G2 to M transition during meristem activation. Taken together, our results suggest that CYCP2;1 acts as a permissive control of cell cycle progression during seedling establishment by directly linking genetic control and nutritional cues with the activity of the core cell cycle machinery.
References provided by Crossref.org
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