• Je něco špatně v tomto záznamu ?

CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis

L. Peng, A. Skylar, PL. Chang, K. Bisova, X. Wu,

. 2014 ; 393 (1) : 160-70.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.

Perzistentní odkaz   https://www.medvik.cz/link/bmc15008013

In higher plants, cell cycle activation in the meristems at germination is essential for the initiation of post-embryonic development. We previously identified the signaling pathways of homeobox transcription factor STIMPY and metabolic sugars as two interacting branches of the regulatory network that is responsible for activating meristematic tissue proliferation in Arabidopsis. In this study, we found that CYCP2;1 is both a direct target of STIMPY transcriptional activation and an early responder to sugar signals. Genetic and molecular studies show that CYCP2;1 physically interacts with three of the five mitotic CDKs in Arabidopsis, and is required for the G2 to M transition during meristem activation. Taken together, our results suggest that CYCP2;1 acts as a permissive control of cell cycle progression during seedling establishment by directly linking genetic control and nutritional cues with the activity of the core cell cycle machinery.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15008013
003      
CZ-PrNML
005      
20150317102004.0
007      
ta
008      
150306s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ydbio.2014.06.008 $2 doi
035    __
$a (PubMed)24951878
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Peng, Linda $u Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
245    10
$a CYCP2;1 integrates genetic and nutritional information to promote meristem cell division in Arabidopsis / $c L. Peng, A. Skylar, PL. Chang, K. Bisova, X. Wu,
520    9_
$a In higher plants, cell cycle activation in the meristems at germination is essential for the initiation of post-embryonic development. We previously identified the signaling pathways of homeobox transcription factor STIMPY and metabolic sugars as two interacting branches of the regulatory network that is responsible for activating meristematic tissue proliferation in Arabidopsis. In this study, we found that CYCP2;1 is both a direct target of STIMPY transcriptional activation and an early responder to sugar signals. Genetic and molecular studies show that CYCP2;1 physically interacts with three of the five mitotic CDKs in Arabidopsis, and is required for the G2 to M transition during meristem activation. Taken together, our results suggest that CYCP2;1 acts as a permissive control of cell cycle progression during seedling establishment by directly linking genetic control and nutritional cues with the activity of the core cell cycle machinery.
650    _2
$a Arabidopsis $x embryologie $7 D017360
650    _2
$a proteiny huseníčku $x biosyntéza $x genetika $x metabolismus $7 D029681
650    _2
$a buněčné dělení $x genetika $7 D002455
650    _2
$a proliferace buněk $7 D049109
650    _2
$a cyklin-dependentní kinasy $x biosyntéza $7 D018844
650    _2
$a cykliny $x biosyntéza $x genetika $x metabolismus $7 D016213
650    _2
$a regulace genové exprese u rostlin $7 D018506
650    _2
$a rostlinné geny $7 D017343
650    _2
$a homeodoménové proteiny $x genetika $7 D018398
650    _2
$a meristém $x cytologie $x embryologie $7 D018519
650    _2
$a semenáček $x genetika $7 D036226
650    _2
$a sacharosa $x farmakologie $7 D013395
650    _2
$a aktivace transkripce $7 D015533
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a Research Support, U.S. Gov't, Non-P.H.S. $7 D013486
700    1_
$a Skylar, Anna $u Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
700    1_
$a Chang, Peter L $u Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
700    1_
$a Bisova, Katerina $u Laboratory of Cell Cycles of Algae, Centre Algatech, Institute of Microbiology, Academy of Sciences of the Czech Republic, Třeboň, Czech Republic.
700    1_
$a Wu, Xuelin $u Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: xuelinwu@usc.edu.
773    0_
$w MED00013105 $t Developmental biology $x 1095-564X $g Roč. 393, č. 1 (2014), s. 160-70
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24951878 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150306 $b ABA008
991    __
$a 20150317102247 $b ABA008
999    __
$a ok $b bmc $g 1065286 $s 890813
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 393 $c 1 $d 160-70 $i 1095-564X $m Developmental biology $n Dev Biol $x MED00013105
LZP    __
$a Pubmed-20150306

Najít záznam

Citační ukazatele

Možnosti archivace