Ubiquitous occurrence of pharmaceuticals in aquatic environment results in concern about potential adverse the effects on nontarget organisms. In water, drugs are present in complex mixtures, in which complicated interactions affect toxicity of single components. The purpose of this study was to examine effect of 35-day-long exposure to mixture of ibuprofen, diclofenac, and carbamazepine on the mortality, growth, early ontogeny, and histopathological changes in tench (Tinca tinca). Early life stage toxicity test was carried out using a modified protocol according to OECD guideline 210. Exposure to mixture of pharmaceuticals at concentration of 60 μg · L(-1) for each substance was associated with significant increase in mortality, as well as significant increase in growth and elevated incidence of malformations. Any of the tested concentrations resulted in histopathological changes of liver, kidney, skin, or gill. After fourteen days of exposure there was short-term delay of development related to increased concentrations of pharmaceuticals in the mixture (2, 20, and 60 μg · L(-1)). Environmentally relevant concentrations (0.02; and 0.2 μg · L(-1)) used in this experiment did not result in toxic impairment of tench.

Department of Pathological Morphology and Parasitology University of Veterinary and Pharmaceutical Sciences Brno Palackeho tr 1 3 612 42 Brno Czech Republic

Department of Veterinary Public Health and Animal Welfare University of Veterinary and Pharmaceutical Sciences Brno Palackeho tr 1 3 61242 Brno Czech Republic

Institute of Vertebrate Biology Academy of Sciences of the Czech Republic v v i Kvetna 8 603 65 Brno Czech Republic

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