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Inflammatory myopathy associated with statins: report of three cases
K. Kuncova, M. Sedlackova, J. Vencovsky, H. Mann, M. Tomcik, L. Wenchich, J. Zamecnik,
Jazyk angličtina Země Japonsko
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
- MeSH
- hypercholesterolemie farmakoterapie MeSH
- kosterní svaly účinky léků patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- myozitida chemicky indukované patologie MeSH
- senioři MeSH
- statiny škodlivé účinky farmakologie terapeutické užití MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
Citace poskytuje Crossref.org
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