• Something wrong with this record ?

Systemic and local inflammatory response in women with preterm prelabor rupture of membranes

T. Cobo, B. Jacobsson, M. Kacerovsky, DM. Hougaard, K. Skogstrand, E. Gratacós, M. Palacio,

. 2014 ; 9 (1) : e85277.

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc15008371

OBJECTIVE: To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC). METHODOLOGY: A prospective study was performed in 58 women with PPROM before 34+0 weeks of gestational age. Twenty-six proteins were analyzed by a multiple immunoassay in samples of amniotic fluid, serum, cervix and vagina. Association of an inflammatory response in the invasive and non-invasive samples with MIAC was investigated. RESULTS: The rate of MIAC was 36.2% (21/58). Both amniotic fluid IL-6 and cervical C-reactive protein (CRP) showed to be independent predictors of MIAC. A cut-off level of cervical CRP≥1836 pg/mL showed a detection rate of 75%, false positive rate of 19% and positive and negative predictive values to predict MIAC of 67% and 87%, respectively. There were no independent biomarkers of MIAC either in the serum or vaginal compartment. CONCLUSION: A cervical inflammatory response mediated by CRP was observed in PPROM women with MIAC. Evaluation of serum or vaginal samples did not add valuable information regarding the outcome evaluated.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15008371
003      
CZ-PrNML
005      
20150306133247.0
007      
ta
008      
150306s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1371/journal.pone.0085277 $2 doi
035    __
$a (PubMed)24465522
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Cobo, Teresa $u Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.
245    10
$a Systemic and local inflammatory response in women with preterm prelabor rupture of membranes / $c T. Cobo, B. Jacobsson, M. Kacerovsky, DM. Hougaard, K. Skogstrand, E. Gratacós, M. Palacio,
520    9_
$a OBJECTIVE: To evaluate the inflammatory pattern in maternal circulation, amniotic cavity, cervix and vagina from women with preterm prelabor rupture of membranes (PPROM) considering the occurrence of microbial invasion of the amniotic cavity (MIAC). METHODOLOGY: A prospective study was performed in 58 women with PPROM before 34+0 weeks of gestational age. Twenty-six proteins were analyzed by a multiple immunoassay in samples of amniotic fluid, serum, cervix and vagina. Association of an inflammatory response in the invasive and non-invasive samples with MIAC was investigated. RESULTS: The rate of MIAC was 36.2% (21/58). Both amniotic fluid IL-6 and cervical C-reactive protein (CRP) showed to be independent predictors of MIAC. A cut-off level of cervical CRP≥1836 pg/mL showed a detection rate of 75%, false positive rate of 19% and positive and negative predictive values to predict MIAC of 67% and 87%, respectively. There were no independent biomarkers of MIAC either in the serum or vaginal compartment. CONCLUSION: A cervical inflammatory response mediated by CRP was observed in PPROM women with MIAC. Evaluation of serum or vaginal samples did not add valuable information regarding the outcome evaluated.
650    _2
$a dospělí $7 D000328
650    _2
$a plodová voda $x chemie $x mikrobiologie $7 D000653
650    _2
$a C-reaktivní protein $x metabolismus $7 D002097
650    _2
$a cervix uteri $x chemie $x mikrobiologie $7 D002584
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a předčasný odtok plodové vody $x krev $x mikrobiologie $7 D005322
650    _2
$a gestační stáří $7 D005865
650    _2
$a gramnegativní bakteriální infekce $x krev $x mikrobiologie $7 D016905
650    _2
$a grampozitivní bakteriální infekce $x krev $x mikrobiologie $7 D016908
650    _2
$a lidé $7 D006801
650    _2
$a novorozenec $7 D007231
650    _2
$a zánět $x krev $x mikrobiologie $7 D007249
650    _2
$a interleukin-6 $x krev $7 D015850
650    _2
$a mykózy $x krev $x mikrobiologie $7 D009181
650    _2
$a předčasná porodní činnost $x krev $x mikrobiologie $7 D007752
650    _2
$a těhotenství $7 D011247
650    _2
$a prospektivní studie $7 D011446
650    _2
$a vagina $x chemie $x mikrobiologie $7 D014621
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Jacobsson, Bo $u Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden ; Institute of Public Health, Oslo, Norway.
700    1_
$a Kacerovsky, Marian $u Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Czech Republic.
700    1_
$a Hougaard, David M $u Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
700    1_
$a Skogstrand, Kristin $u Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
700    1_
$a Gratacós, Eduard $u Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.
700    1_
$a Palacio, Montse $u Maternal-Fetal Medicine Department, ICGON, Hospital Clınic, Universitat de Barcelona, Barcelona, Spain; Fetal and Perinatal Medicine Research Group, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.
773    0_
$w MED00180950 $t PloS one $x 1932-6203 $g Roč. 9, č. 1 (2014), s. e85277
856    41
$u https://pubmed.ncbi.nlm.nih.gov/24465522 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150306 $b ABA008
991    __
$a 20150306133518 $b ABA008
999    __
$a ok $b bmc $g 1065644 $s 891171
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 9 $c 1 $d e85277 $i 1932-6203 $m PLoS One $n PLoS One $x MED00180950
LZP    __
$a Pubmed-20150306

Find record

Citation metrics

Archiving options