-
Something wrong with this record ?
Oxidative stress responses in zebrafish Danio rerio after subchronic exposure to atrazine
J. Blahová, L. Plhalová, M. Hostovský, L. Divišová, R. Dobšíková, I. Mikulíková, S. Stěpánová, Z. Svobodová,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Atrazine toxicity MeSH
- Biomarkers metabolism MeSH
- Water Pollutants, Chemical toxicity MeSH
- Zebrafish growth & development metabolism MeSH
- Glutathione Peroxidase metabolism MeSH
- Glutathione Reductase metabolism MeSH
- Glutathione Transferase metabolism MeSH
- Inactivation, Metabolic MeSH
- Mortality MeSH
- Oxidative Stress drug effects MeSH
- Superoxide Dismutase metabolism MeSH
- Toxicity Tests, Subchronic MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Atrazine is one of the most used pesticides all over the world and it is frequently detected in surface water. The aim of this study was to investigate if zebrafish exposure to atrazine could induce oxidative stress and changes in detoxifying system. Juvenile fish were exposed to sublethal concentrations of 0.3, 3, 30, or 90 μg L(-1) for 28 days. The level of oxidized lipids increased in experimental groups exposed to atrazine at 30 and 90 μg L(-1) compared to control. Activity of glutathione S-transferase decreased in group with the highest concentration compared to control. A significant decline was observed in catalase activity in all experimental groups compared to control. Activity of superoxide dismutase increased only in experimental group exposed to atrazine at 30 μg L(-1) compared to control. Activity of glutathione peroxidase and reductase (GR) increased in experimental groups exposed to atrazine at 0.3 (only for GR activity) and 90 μg L(-1) compared to control. Our results showed that atrazine exposure had profound influence on the oxidative stress markers and detoxifying enzyme of the exposed zebrafish. The changes in antioxidant enzyme activities could be an adaptive response to protect the fish from the atrazine-induced toxicity.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15008628
- 003
- CZ-PrNML
- 005
- 20150325101146.0
- 007
- ta
- 008
- 150306s2013 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.fct.2013.02.041 $2 doi
- 035 __
- $a (PubMed)23499751
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Blahová, Jana $u Department of Veterinary Public Health and Toxicology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, Brno 612 42, Czech Republic. Electronic address: blahovaj@vfu.cz.
- 245 10
- $a Oxidative stress responses in zebrafish Danio rerio after subchronic exposure to atrazine / $c J. Blahová, L. Plhalová, M. Hostovský, L. Divišová, R. Dobšíková, I. Mikulíková, S. Stěpánová, Z. Svobodová,
- 520 9_
- $a Atrazine is one of the most used pesticides all over the world and it is frequently detected in surface water. The aim of this study was to investigate if zebrafish exposure to atrazine could induce oxidative stress and changes in detoxifying system. Juvenile fish were exposed to sublethal concentrations of 0.3, 3, 30, or 90 μg L(-1) for 28 days. The level of oxidized lipids increased in experimental groups exposed to atrazine at 30 and 90 μg L(-1) compared to control. Activity of glutathione S-transferase decreased in group with the highest concentration compared to control. A significant decline was observed in catalase activity in all experimental groups compared to control. Activity of superoxide dismutase increased only in experimental group exposed to atrazine at 30 μg L(-1) compared to control. Activity of glutathione peroxidase and reductase (GR) increased in experimental groups exposed to atrazine at 0.3 (only for GR activity) and 90 μg L(-1) compared to control. Our results showed that atrazine exposure had profound influence on the oxidative stress markers and detoxifying enzyme of the exposed zebrafish. The changes in antioxidant enzyme activities could be an adaptive response to protect the fish from the atrazine-induced toxicity.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a atrazin $x toxicita $7 D001280
- 650 _2
- $a biologické markery $x metabolismus $7 D015415
- 650 _2
- $a glutathionperoxidasa $x metabolismus $7 D005979
- 650 _2
- $a glutathionreduktasa $x metabolismus $7 D005980
- 650 _2
- $a glutathiontransferasa $x metabolismus $7 D005982
- 650 _2
- $a metabolická inaktivace $7 D008658
- 650 _2
- $a mortalita $7 D009026
- 650 _2
- $a oxidační stres $x účinky léků $7 D018384
- 650 _2
- $a superoxiddismutasa $x metabolismus $7 D013482
- 650 _2
- $a testy subchronické toxicity $7 D059550
- 650 _2
- $a chemické látky znečišťující vodu $x toxicita $7 D014874
- 650 _2
- $a dánio pruhované $x růst a vývoj $x metabolismus $7 D015027
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Plhalová, Lucie
- 700 1_
- $a Hostovský, Martin
- 700 1_
- $a Divišová, Lenka
- 700 1_
- $a Dobšíková, Radka
- 700 1_
- $a Mikulíková, Ivana
- 700 1_
- $a Stěpánová, Stanislava
- 700 1_
- $a Svobodová, Zdeňka
- 773 0_
- $w MED00001825 $t Food and chemical toxicology an international journal published for the British Industrial Biological Research Association $x 1873-6351 $g Roč. 61, č. - (2013), s. 82-5
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/23499751 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150306 $b ABA008
- 991 __
- $a 20150325101435 $b ABA008
- 999 __
- $a ok $b bmc $g 1065901 $s 891428
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2013 $b 61 $c - $d 82-5 $i 1873-6351 $m Food and chemical toxicology $n Food Chem Toxicol $x MED00001825
- LZP __
- $a Pubmed-20150306
