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Fluorované fosfonáty jako činidla pro zavedení fluorovaných funkčních skupin
[Fluorinated phoshonates as reagents for the introduction of fluorinated functional groups]
Petr Beier, Stanislav Opekar
Language Czech Country Czech Republic
Document type Research Support, Non-U.S. Gov't
- MeSH
- Biological Transport, Active MeSH
- Alkylation MeSH
- Antiviral Agents MeSH
- Diphosphonates * chemistry classification MeSH
- Pharmacologic Actions MeSH
- Fluorine chemistry MeSH
- Enzyme Inhibitors MeSH
- Humans MeSH
- Chemistry, Organic MeSH
- Organophosphonates * chemistry classification MeSH
- Organic Chemistry Phenomena MeSH
- Structure-Activity Relationship * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
This review introduces β-fluorophosphonates as useful synthons and fluoroalkyl transfer reagents. The remarkable biological activity of the phosphonates is also mentioned. The main emphasis is put on synthetic applications of the following fluorinated phosphonates: diethyl (difluoromethyl)phosphonate (1), diethyl (trifluoromethyl)phosphonate (2), tetraethyl (fluoromethylene)bis¬phosphonate (3), diethyl [(fluoromethyl) (phenylsulfonyl)methyl]phosphonate (McCathy’s reagent) (4), and diethyl (fluoronitromethyl)phosphonate (5). The review is focused on the chemistry of the synthons.
Fluorinated phoshonates as reagents for the introduction of fluorinated functional groups
Literatura
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- $a This review introduces β-fluorophosphonates as useful synthons and fluoroalkyl transfer reagents. The remarkable biological activity of the phosphonates is also mentioned. The main emphasis is put on synthetic applications of the following fluorinated phosphonates: diethyl (difluoromethyl)phosphonate (1), diethyl (trifluoromethyl)phosphonate (2), tetraethyl (fluoromethylene)bis¬phosphonate (3), diethyl [(fluoromethyl) (phenylsulfonyl)methyl]phosphonate (McCathy’s reagent) (4), and diethyl (fluoronitromethyl)phosphonate (5). The review is focused on the chemistry of the synthons.
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