Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

DISP3 promotes proliferation and delays differentiation of neural progenitor cells

M. Zíková, J. Konířová, K. Ditrychová, A. Corlett, M. Kolář, P. Bartůněk,

. 2014 ; 588 (21) : 4071-7.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15014032

DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15014032
003      
CZ-PrNML
005      
20150427102737.0
007      
ta
008      
150420s2014 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.febslet.2014.09.036 $2 doi
035    __
$a (PubMed)25281927
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Zíková, Martina $u Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
245    10
$a DISP3 promotes proliferation and delays differentiation of neural progenitor cells / $c M. Zíková, J. Konířová, K. Ditrychová, A. Corlett, M. Kolář, P. Bartůněk,
520    9_
$a DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation.
650    _2
$a mozek $x cytologie $7 D001921
650    12
$a buněčná diferenciace $7 D002454
650    _2
$a buněčné linie $7 D002460
650    _2
$a proliferace buněk $7 D049109
650    _2
$a regulace genové exprese $7 D005786
650    _2
$a lidé $7 D006801
650    _2
$a metabolismus lipidů $7 D050356
650    _2
$a membránové proteiny $x genetika $x metabolismus $7 D008565
650    _2
$a nervové kmenové buňky $x cytologie $x metabolismus $7 D058953
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Konířová, Jana $u Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Ditrychová, Karolína $u Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Corlett, Alicia $u Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Kolář, Michal $u Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
700    1_
$a Bartůněk, Petr $u Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic. Electronic address: bartunek@img.cas.cz.
773    0_
$w MED00001785 $t FEBS letters $x 1873-3468 $g Roč. 588, č. 21 (2014), s. 4071-7
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25281927 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20150420 $b ABA008
991    __
$a 20150427103041 $b ABA008
999    __
$a ok $b bmc $g 1071613 $s 896910
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 588 $c 21 $d 4071-7 $i 1873-3468 $m FEBS letters $n FEBS Lett $x MED00001785
LZP    __
$a Pubmed-20150420

Najít záznam

Citační ukazatele

Možnosti archivace