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Effect of age at exposure in 11 underground miners studies
L. Tomasek,
Language English Country England, Great Britain
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24751983
DOI
10.1093/rpd/ncu068
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Mining * MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Lung Neoplasms etiology MeSH
- Neoplasms, Radiation-Induced etiology MeSH
- Follow-Up Studies MeSH
- Occupational Exposure adverse effects MeSH
- Prognosis MeSH
- Radioactive Pollutants adverse effects MeSH
- Radon adverse effects MeSH
- Risk Factors MeSH
- Aged MeSH
- Uranium adverse effects MeSH
- Age Factors MeSH
- Dose-Response Relationship, Radiation MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
Eleven underground miners studies evaluated the risk of lung cancer from exposure in underground mines. Nearly 68,000 miners were included in the joint study, contributing to nearly 2700 lung cancers. The resulting model of the Biological Effects of Ionizing Radiation (BEIR) VI Committee considered linear exposure response relationship, which was modified by time since exposure (TE), attained age and exposure rate. The effect of age at exposure (AE) was not explicitly evaluated. The presentation aims to show that the modifying effect of AE is substantial if time-since-exposure modification is simultaneously used in the model. When the excess relative risk per unit exposure (ERR/WLM) is adjusted for TE, the ERR/WLM corresponding to AE<15 is 0.013 and in subsequent categories decreased gradually up to the AE of 40 and more years, which was only 0.004. In comparison with the BEIR VI model, the present model predicts higher risks at younger ages and the risk decreases more rapidly.
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