-
Something wrong with this record ?
Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients
R. Prikryl, L. Ustohal, HP. Kucerova, T. Kasparek, J. Jarkovsky, V. Hublova, M. Vrzalova, E. Ceskova,
Language English Country England, Great Britain
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- MeSH
- Adult MeSH
- Double-Blind Method MeSH
- Smoking psychology therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Smoking Cessation methods MeSH
- Prefrontal Cortex physiology MeSH
- Smoking Prevention MeSH
- Schizophrenic Psychology * MeSH
- Transcranial Magnetic Stimulation * MeSH
- Symptom Assessment MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
INTRODUCTION: High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) seemed to decrease tobacco consumption and craving in nicotine-dependent people without psychiatric disorder or otherwise healthy people. Even if the prevalence of cigarette smoking in schizophrenia patients is high and estimated to be between 45% and 88%, this technique has not been systematically studied in this indication in schizophrenia yet. THE AIM OF THE STUDY: The aim of this study was to test the ability of high-frequency (10Hz) rTMS over the left DLPFC to decrease cigarette consumption in schizophrenia patients. METHODS: The study included 35 male schizophrenia patients on stable antipsychotic medication. The patients were divided into two groups: the first (18 patients) were actively stimulated and the second (17 patients) underwent sham (placebo) stimulation. The sham rTMS was administered using a purpose-built sham coil that was identical in appearance to the real coil and made the same noise but did not deliver a substantial stimulus. The rTMS was administered at the stimulation parameters: location (left dorsolateral prefrontal cortex: DLPFC), intensity of magnetic stimulation in % of motor threshold (110%), stimulation frequency (10Hz), number of trains (20), single train duration (10s), inter-train interval (30s), and total number of stimulation sessions (21). In each stimulation session, 2000TMSpulses were given, with a total of 42,000pulses per treatment course. Patients noted the number of cigarettes smoked in the 7days before treatment, during the whole stimulation treatment (21days), and again for a 7-day period after treatment. RESULTS: Cigarette consumption was statistically significantly lower in the actively stimulated patients than in the sham rTMS group as early as the first week of stimulation. No statistically relevant correlations were found in the changes of ongoing negative or depressive schizophrenia symptoms and the number of cigarettes smoked. CONCLUSION: High-frequency rTMS over the left DLPFC has the ability to decrease the number of cigarettes smoked in schizophrenia patients.
CEITEC Central European Institute of Technology Masaryk University Czech Republic
Department of Psychiatry Faculty of Medicine Masaryk University Brno Czech Republic
Department of Psychiatry University Hospital Brno Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15014580
- 003
- CZ-PrNML
- 005
- 20170213141849.0
- 007
- ta
- 008
- 150420s2014 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.pnpbp.2013.10.019 $2 doi
- 035 __
- $a (PubMed)24211840
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Prikryl, Radovan $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Psychiatry, University Hospital Brno, Czech Republic. Electronic address: radovan.prikryl@post.cz.
- 245 10
- $a Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients / $c R. Prikryl, L. Ustohal, HP. Kucerova, T. Kasparek, J. Jarkovsky, V. Hublova, M. Vrzalova, E. Ceskova,
- 520 9_
- $a INTRODUCTION: High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) seemed to decrease tobacco consumption and craving in nicotine-dependent people without psychiatric disorder or otherwise healthy people. Even if the prevalence of cigarette smoking in schizophrenia patients is high and estimated to be between 45% and 88%, this technique has not been systematically studied in this indication in schizophrenia yet. THE AIM OF THE STUDY: The aim of this study was to test the ability of high-frequency (10Hz) rTMS over the left DLPFC to decrease cigarette consumption in schizophrenia patients. METHODS: The study included 35 male schizophrenia patients on stable antipsychotic medication. The patients were divided into two groups: the first (18 patients) were actively stimulated and the second (17 patients) underwent sham (placebo) stimulation. The sham rTMS was administered using a purpose-built sham coil that was identical in appearance to the real coil and made the same noise but did not deliver a substantial stimulus. The rTMS was administered at the stimulation parameters: location (left dorsolateral prefrontal cortex: DLPFC), intensity of magnetic stimulation in % of motor threshold (110%), stimulation frequency (10Hz), number of trains (20), single train duration (10s), inter-train interval (30s), and total number of stimulation sessions (21). In each stimulation session, 2000TMSpulses were given, with a total of 42,000pulses per treatment course. Patients noted the number of cigarettes smoked in the 7days before treatment, during the whole stimulation treatment (21days), and again for a 7-day period after treatment. RESULTS: Cigarette consumption was statistically significantly lower in the actively stimulated patients than in the sham rTMS group as early as the first week of stimulation. No statistically relevant correlations were found in the changes of ongoing negative or depressive schizophrenia symptoms and the number of cigarettes smoked. CONCLUSION: High-frequency rTMS over the left DLPFC has the ability to decrease the number of cigarettes smoked in schizophrenia patients.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a dvojitá slepá metoda $7 D004311
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prefrontální mozková kůra $x fyziologie $7 D017397
- 650 12
- $a schizofrenie (psychologie) $7 D012565
- 650 _2
- $a kouření $x psychologie $x terapie $7 D012907
- 650 _2
- $a odvykání kouření $x metody $7 D016540
- 650 _2
- $a určení symptomu $7 D063189
- 650 12
- $a transkraniální magnetická stimulace $7 D050781
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a prevence kouření $7 D000074606
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Ustohal, Libor $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Psychiatry, University Hospital Brno, Czech Republic.
- 700 1_
- $a Kucerova, Hana Prikrylova $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Psychiatry, University Hospital Brno, Czech Republic.
- 700 1_
- $a Kasparek, Tomas $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Psychiatry, University Hospital Brno, Czech Republic.
- 700 1_
- $a Jarkovsky, Jiri $u Institute for Biostatistics and Analyses of the Faculty of Medicine, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Hublová, Veronika $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic. $7 xx0161774
- 700 1_
- $a Vrzalova, Michaela $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Psychiatry, University Hospital Brno, Czech Republic.
- 700 1_
- $a Ceskova, Eva $u CEITEC - Central European Institute of Technology, Masaryk University, Czech Republic; Department of Psychiatry Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Psychiatry, University Hospital Brno, Czech Republic.
- 773 0_
- $w MED00003930 $t Progress in neuro-psychopharmacology & biological psychiatry $x 1878-4216 $g Roč. 49, č. - (2014), s. 30-5
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/24211840 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150420 $b ABA008
- 991 __
- $a 20170213142031 $b ABA008
- 999 __
- $a ok $b bmc $g 1072161 $s 897458
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 49 $c - $d 30-5 $i 1878-4216 $m Progress in neuro-psychopharmacology & biological psychiatry $n Prog Neuropsychopharmacol Biol Psychiatry $x MED00003930
- LZP __
- $a Pubmed-20150420
