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Base-mediated intramolecular C- and N-arylation of N,N-disubstituted 2-nitrobenzenesulfonamides: advanced intermediates for the synthesis of diverse nitrogenous heterocycles
P. Smyslová, K. Kisseljova, V. Krchňák,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25076047
DOI
10.1021/co5000739
Knihovny.cz E-zdroje
- MeSH
- dusík chemie MeSH
- dusíkaté sloučeniny chemie MeSH
- heterocyklické sloučeniny chemická syntéza chemie MeSH
- molekulární struktura MeSH
- sulfonamidy chemie MeSH
- uhlík chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Structural and electronic features that facilitate and direct the intramolecular C- and N-arylation of 2-alkyl-2-{[N-(benzyl)-2-nitrophenyl]sulfonamido}acetic acid esters and amides were examined. The substitution pattern and amino acid carboxy-terminal functionality determined the arylation position. C/N-arylated products represent advanced intermediates for combinatorial synthesis of diverse nitrogenous heterocycles, including indazoles, quinazolinones, quinoxalinones, and 3-amino-2-oxindoles.
Citace poskytuje Crossref.org
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