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Sleep apnea prevalence in acute myocardial infarction--the Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study
O. Ludka, R. Stepanova, M. Vyskocilova, L. Galkova, M. Mikolaskova, M. Belehrad, J. Kostalova, Z. Mihalova, A. Drozdova, J. Hlasensky, M. Gacik, L. Pudilova, T. Mikusova, B. Fischerova, F. Sert-Kuniyoshi, VK. Somers, J. Spinar, T. Kara,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
NT11401
MZ0
CEP - Centrální evidence projektů
- MeSH
- časové faktory MeSH
- infarkt myokardu diagnóza epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- prevalence MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- syndromy spánkové apnoe diagnóza epidemiologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: While sleep apnea (SA) might be a modifiable cardiovascular risk factor, recent data suggest that SA is severely underdiagnosed in patients after acute myocardial infarction (MI). There is limited evidence about day-night variation of onset of MI on dependence of having SA. We therefore investigated the prevalence of SA and examined the day-night variation of onset of MI in acute MI patients. METHODS: We prospectively studied 782 consecutive patients admitted to the hospital with the diagnosis of acute MI. All subjects underwent sleep evaluations using a portable device after at least 48 h post-admission. Using the apnea-hypopnea index (AHI), groups were defined as patients without SA (<5 events/h), mild SA (5-15 events/h), moderate SA (15-30 events/h), and severe SA (≥ 30 events/h). RESULTS: Almost all patients (98%) underwent urgent coronary angiography and 91% of patients underwent primary PCI. Using a threshold of AHI ≥ 5 events/h, SA was present in 65.7% of patients after acute MI. Mild SA was present in 32.6%, moderate in 20.4% and severe in 12.7%. The day-night variation in the onset of MI in all groups of SA patients was similar to that observed in non-SA patients. From 6 AM to 12 PM, the frequency of MI was higher in both SA and non-SA patients, as compared to the interval from 12 AM to 6 AM (all p<0.05). CONCLUSION: There is a high prevalence of SA in patients presenting with acute MI. Peak time of MI onset in SA patients was between 6 AM and noon, similar to that in the general population. Whether diagnosis and treatment of SA after MI will significantly improve outcomes in these patients remains to be determined.
Department of Cardiovascular Disease St Anne's University Hospital Brno Czech Republic
Department of Internal Medicine and Cardiology University Hospital Brno Czech Republic
Faculty of Medicine Masaryk University Brno Czech Republic
International Clinical Research Center St Anne's University Hospital Brno Czech Republic
Citace poskytuje Crossref.org
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