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Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma
L. Kubiczkova, L. Pour, L. Sedlarikova, R. Hajek, S. Sevcikova,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NT12130
MZ0
CEP - Centrální evidence projektů
NT14575
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
Zdroj
Zdroj
Free Medical Journals od 2000
PubMed Central od 2000
Europe PubMed Central od 2000 do 2020
ProQuest Central od 2000-07-01
Open Access Digital Library od 2000-01-01
Open Access Digital Library od 2006-01-01
Open Access Digital Library od 2012-01-01
Medline Complete (EBSCOhost) od 2007-01-01
Health & Medicine (ProQuest) od 2000-07-01
Wiley-Blackwell Open Access Titles od 2000
ROAD: Directory of Open Access Scholarly Resources od 2001
Odkazy
PubMed
24712303
DOI
10.1111/jcmm.12279
Knihovny.cz E-zdroje
- MeSH
- inhibitory proteasomu terapeutické užití MeSH
- lidé MeSH
- mnohočetný myelom farmakoterapie enzymologie MeSH
- proteasomový endopeptidasový komplex chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Inhibition of proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, has emerged as a powerful strategy for treatment of multiple myeloma (MM), a plasma cell malignancy. First-in-class agent, bortezomib, has demonstrated great positive therapeutic efficacy in MM, both in pre-clinical and in clinical studies. However, despite its high efficiency, a large proportion of patients do not achieve sufficient clinical response. Therefore, the development of a second-generation of proteasome inhibitors (PIs) with improved pharmacological properties was needed. Recently, several of these new agents have been introduced into clinics including carfilzomib, marizomib and ixazomib. Further, new orally administered second-generation PI oprozomib is being investigated. This review provides an overview of main mechanisms of action of PIs in MM, focusing on the ongoing development and progress of novel anti-proteasome therapeutics.
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