-
Je něco špatně v tomto záznamu ?
In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier
L. Cahlíková, DI. Pérez, Š. Štěpánková, J. Chlebek, M. Šafratová, A. Hošt'álková, L. Opletal,
Journal of natural products.
2015 ;
78 (6) :
1189-92.
[pub] 20150601
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc15031333
- MeSH
- acetylcholinesterasa metabolismus MeSH
- alkaloidy amarylkovitých farmakologie MeSH
- Alzheimerova nemoc farmakoterapie MeSH
- biologický transport účinky léků MeSH
- cholinesterasové inhibitory farmakologie MeSH
- hematoencefalická bariéra účinky léků MeSH
- lidé MeSH
- molekulární struktura MeSH
- techniky in vitro MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Alzheimer's disease is the most common cause of dementia. Currently, acetylcholinesterase (AChE) inhibition is the most widely used therapeutic treatment. A large number of naturally occurring compounds have been found to inhibit AChE. In this report the mechanism of AChE inhibition of two Amaryllidaceae alkaloids, 8-O-demethylmaritidine (1) and undulatine (2), and their possible penetration across the blood-brain barrier have been studied. Both compounds act via a mixed inhibition mechanism. Based on the parallel artificial permeation assay (PAMPA) for the prediction of blood-brain barrier (BBB) penetration, only 2 should be able to cross the BBB by passive permeation.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15031333
- 003
- CZ-PrNML
- 005
- 20170124143155.0
- 007
- ta
- 008
- 151005s2015 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1021/acs.jnatprod.5b00191 $2 doi
- 035 __
- $a (PubMed)26030662
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Cahlíková, Lucie $u †ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
- 245 10
- $a In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier / $c L. Cahlíková, DI. Pérez, Š. Štěpánková, J. Chlebek, M. Šafratová, A. Hošt'álková, L. Opletal,
- 520 9_
- $a Alzheimer's disease is the most common cause of dementia. Currently, acetylcholinesterase (AChE) inhibition is the most widely used therapeutic treatment. A large number of naturally occurring compounds have been found to inhibit AChE. In this report the mechanism of AChE inhibition of two Amaryllidaceae alkaloids, 8-O-demethylmaritidine (1) and undulatine (2), and their possible penetration across the blood-brain barrier have been studied. Both compounds act via a mixed inhibition mechanism. Based on the parallel artificial permeation assay (PAMPA) for the prediction of blood-brain barrier (BBB) penetration, only 2 should be able to cross the BBB by passive permeation.
- 650 _2
- $a acetylcholinesterasa $x metabolismus $7 D000110
- 650 _2
- $a Alzheimerova nemoc $x farmakoterapie $7 D000544
- 650 _2
- $a alkaloidy amarylkovitých $x farmakologie $7 D047151
- 650 _2
- $a biologický transport $x účinky léků $7 D001692
- 650 _2
- $a hematoencefalická bariéra $x účinky léků $7 D001812
- 650 _2
- $a cholinesterasové inhibitory $x farmakologie $7 D002800
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a techniky in vitro $7 D066298
- 650 _2
- $a molekulární struktura $7 D015394
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Pérez, Daniel I $u ‡Centro de Investigaciones Biológicas, Avenida Ramiro de Maeztu, 9, 28040 Madrid, Spain.
- 700 1_
- $a Štěpánková, Šárka $u §Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech Republic.
- 700 1_
- $a Chlebek, Jakub $u †ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
- 700 1_
- $a Šafratová, Marcela $u †ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. $7 xx0210141
- 700 1_
- $a Hošt'álková, Anna $u †ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
- 700 1_
- $a Opletal, Lubomír $u †ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
- 773 0_
- $w MED00010055 $t Journal of natural products $x 1520-6025 $g Roč. 78, č. 6 (2015), s. 1189-92
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26030662 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20151005 $b ABA008
- 991 __
- $a 20170124143311 $b ABA008
- 999 __
- $a ok $b bmc $g 1092209 $s 914459
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 78 $c 6 $d 1189-92 $e 20150601 $i 1520-6025 $m Journal of natural products $n J Nat Prod $x MED00010055
- LZP __
- $a Pubmed-20151005
