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Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma: A treatment planning case report
T. Kazda, P. Pospisil, M. Vrzal, O. Sevela, T. Prochazka, R. Jancalek, P. Slampa, NN. Laack,
Language English Country France
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
Grant support
NT14120
MZ0
CEP Register
NT14600
MZ0
CEP Register
- MeSH
- Radiotherapy, Adjuvant methods MeSH
- Antineoplastic Agents, Alkylating therapeutic use MeSH
- Astrocytoma pathology MeSH
- Radiotherapy Dosage MeSH
- Frontal Lobe pathology MeSH
- Brain Damage, Chronic prevention & control MeSH
- Dacarbazine analogs & derivatives therapeutic use MeSH
- Cell Dedifferentiation MeSH
- Glioma drug therapy radiotherapy surgery MeSH
- Hippocampus radiation effects MeSH
- Combined Modality Therapy MeSH
- Cranial Irradiation adverse effects methods MeSH
- Organ Sparing Treatments methods MeSH
- Humans MeSH
- Neoplasm Recurrence, Local drug therapy radiotherapy MeSH
- Young Adult MeSH
- Radiotherapy Planning, Computer-Assisted MeSH
- Disease Progression MeSH
- Radiotherapy, Intensity-Modulated adverse effects methods MeSH
- Supratentorial Neoplasms drug therapy radiotherapy surgery MeSH
- Tumor Burden MeSH
- Check Tag
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
Timing of radiotherapy for low-grade gliomas is still controversial due to concerns of possible adverse late effects. Prevention of possible late cognitive sequelae by hippocampal avoidance has shown promise in phase II trials. A patient with progressive low-grade glioma with gradual dedifferentiation into anaplastic astrocytoma is presented along with description of radiotherapy planning process attempting to spare the hippocampus. To our knowledge, this is the first described case using volumetric modulated arc technique to spare hippocampus during transformed low-grade glioma radiotherapy. Using modern intensity-modulated radiotherapy systems it is possible to selectively spare hippocampus together with other standard organs at risk. For selected patients, an attempt to spare hippocampus can be considered as long as other dose characteristics are not significantly compromised compared to standard treatment plan created without any effort to avoid hippocampus.
References provided by Crossref.org
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