• Something wrong with this record ?

The impact of lifestyle-related risk factors on cardiac response to ischemia and possibilities to restore impaired ischemic tolerance

T. Ravingerová, S. Čarnická, M. Nemčeková, V. Ledvényiová, A. Adameová, V. K. M. Khandelwal, M. Zálešák, F. Kolář

. 2012 ; 61 (Suppl 2) : S1-S10. (88th Physiological days)
. 2012 ; () : S1-S10.

Language English Country Czech Republic

Document type Review

Persistent link   https://www.medvik.cz/link/bmc15032679

Risk factors (RF) of cardiovascular diseases associated with modern lifestyle, such as stress, chronically increased blood pressure, hyperglycemia and dyslipidemia have a negative impact on the heart exposed to ischemia: their may facilitate its lethal injury (myocardial infarction) and occurrence of sudden death due to ventricular arrhythmias. On the other hand, some stressful stimuli related to RF including reactive oxygen species, transient episodes of ischemia (hypoxia), high glucose and other may play a dual role in the pathogenesis of ischemia/reperfusion (I/R) injury (IRI). Besides their deleterious effects, these factors may trigger adaptive processes in the heart resulting in greater resistance against IRI, which is also a characteristic feature of the female myocardium. However, sensitivity to ischemia is increasing with age in both genders. Current research indicates that comorbidity related to lifestyle may impair the cardiac response to acute ischemia not only by interference with pathophysiological mechanisms of IRI per se, but via suppression of intrinsic protective mechanisms in the heart and its ability to tolerate the ischemic challenges, although the role of RF has not been unequivocally proven. Moreover, even pathologically altered myocardium need not completely lose its adaptive potential. In addition, increased ischemic tolerance can be induced by the pleiotropic (independent of the primary) effects of some hypolipidemic and antidiabetic drugs, even in the diseased myocardium. This review addresses the issue of the impact of RF on cellular cardioprotective mechanisms and the possibilities to restore adaptive potential in subjects challenged with several RF. Reactivation of adaptive processes in the myocardium taking into consideration gender and age can contribute to optimalization of antiischemic therapy.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc15032679
003      
CZ-PrNML
005      
20160411155459.0
007      
ta
008      
151012s2012 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932396 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Ravingerová, Táňa, $d 1951- $7 xx0248557 $u Institute for Heart Research, Slovak Academy of Sciences and Centre of Excellence SAS NOREG, Bratislava, Slovakia
245    14
$a The impact of lifestyle-related risk factors on cardiac response to ischemia and possibilities to restore impaired ischemic tolerance / $c T. Ravingerová, S. Čarnická, M. Nemčeková, V. Ledvényiová, A. Adameová, V. K. M. Khandelwal, M. Zálešák, F. Kolář
504    __
$a Literatura
520    9_
$a Risk factors (RF) of cardiovascular diseases associated with modern lifestyle, such as stress, chronically increased blood pressure, hyperglycemia and dyslipidemia have a negative impact on the heart exposed to ischemia: their may facilitate its lethal injury (myocardial infarction) and occurrence of sudden death due to ventricular arrhythmias. On the other hand, some stressful stimuli related to RF including reactive oxygen species, transient episodes of ischemia (hypoxia), high glucose and other may play a dual role in the pathogenesis of ischemia/reperfusion (I/R) injury (IRI). Besides their deleterious effects, these factors may trigger adaptive processes in the heart resulting in greater resistance against IRI, which is also a characteristic feature of the female myocardium. However, sensitivity to ischemia is increasing with age in both genders. Current research indicates that comorbidity related to lifestyle may impair the cardiac response to acute ischemia not only by interference with pathophysiological mechanisms of IRI per se, but via suppression of intrinsic protective mechanisms in the heart and its ability to tolerate the ischemic challenges, although the role of RF has not been unequivocally proven. Moreover, even pathologically altered myocardium need not completely lose its adaptive potential. In addition, increased ischemic tolerance can be induced by the pleiotropic (independent of the primary) effects of some hypolipidemic and antidiabetic drugs, even in the diseased myocardium. This review addresses the issue of the impact of RF on cellular cardioprotective mechanisms and the possibilities to restore adaptive potential in subjects challenged with several RF. Reactivation of adaptive processes in the myocardium taking into consideration gender and age can contribute to optimalization of antiischemic therapy.
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    12
$a ischemická choroba srdeční $x epidemiologie $x patofyziologie $7 D017202
650    _2
$a životní styl $7 D008019
650    _2
$a myokard $x patologie $7 D009206
650    _2
$a reaktivní formy kyslíku $x metabolismus $7 D017382
650    _2
$a reperfuzní poškození myokardu $x patologie $7 D015428
650    12
$a rizikové faktory $7 D012307
655    _2
$a přehledy $7 D016454
700    1_
$a Čarnická, Slávka $7 xx0146449 $u Institute for Heart Research, Slovak Academy of Sciences and Centre of Excellence SAS NOREG, Bratislava, Slovakia
700    1_
$a Nemčeková, M. $7 _AN066161 $u Institute for Heart Research, Slovak Academy of Sciences and Centre of Excellence SAS NOREG, Bratislava, Slovakia
700    1_
$a Ledvényiová, V. $7 _AN070794 $u Institute for Heart Research, Slovak Academy of Sciences and Centre of Excellence SAS NOREG, Bratislava, Slovakia
700    1_
$a Adameová, Adriana $7 xx0064778 $u Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia
700    1_
$a Khandelwal, V. K. M. $u Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
700    1_
$a Zálešák, Marek $7 _AN070793 $u Institute for Heart Research, Slovak Academy of Sciences and Centre of Excellence SAS NOREG, Bratislava, Slovakia
700    1_
$a Kolář, František, $d 1952 říjen 2.- $7 xx0037264 $u Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
773    0_
$t Physiological research. 88th Physiological days $x 0862-8408 $g Roč. 61, Suppl 2 (2012), s. S1-S10 $w MED00003824
773    0_
$t Proceedings of the ... Physiological days $g (2012), s. S1-S10 $w MED00183838
856    41
$u http://www.biomed.cas.cz/physiolres/2012/S2_12.htm $y domovská stránka časopisu - plný text volně přístupný
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20151012121057 $b ABA008
991    __
$a 20160411155541 $b ABA008
999    __
$a ok $b bmc $g 1093569 $s 915808
BAS    __
$a 3
BMC    __
$a 2012 $b 61 $c Suppl 2 $d S1-S10 $i 0862-8408 $m Physiological research $o 88th Physiological days $x MED00003824
BMC    __
$a 2012 $d S1-S10 $m Proceedings of the ... Physiological days $x MED00183838
LZP    __
$c NLK109 $d 20160411 $a NLK 2015-32/mk

Find record

Citation metrics

Archiving options