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Pistacia terebinthus coffee protects against thioacetamide-induced liver injury in rats

I. H. Bahcecioglu, M. Ispiroglu, M. Tuzcu, C. Orhan, M. Ulas, U. Demirel, M. Yalniz, I. H. Özercan, N. Ilhan, K. Sahin

. 2015 ; 58 (2) : 56-61.

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc15040064

AIM/BACKGROUND: Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats. MATERIALS AND METHODS: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively. RESULTS: After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p PTC intake. DISCUSSION AND CONCLUSION: PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway.

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$a Ispiroglu, Murat $u Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey
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$a Tuzcu, Mehmet $u Department of Biology, Firat University Faculty of Medicine, Elazig, Turkey
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$a Orhan, Cemal $u Department of Animal Nutrition, Firat University Faculty of Medicine, Elazig, Turkey
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$a Ulas, Mustafa $u Department of Physiology, Firat University Faculty of Medicine, Elazig, Turkey
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$a Demirel, Ulvi $u Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey
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$a Yalniz, Mehmet $u Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey
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$a Özercan, Ibrahim H. $u Department of Pathology, Firat University Faculty of Medicine, Elazig, Turkey
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$a Ilhan, Necip $u Department of Biochemistry, Firat University Faculty of Medicine, Elazig, Turkey
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$a Sahin, Kazim $u Department of Animal Nutrition, Firat University Faculty of Medicine, Elazig, Turkey
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