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A Deep Insight Into the Sialotranscriptome of the Chagas Disease Vector, Panstrongylus megistus (Hemiptera: Heteroptera)
JM. Ribeiro, A. Schwarz, IM. Francischetti,
Language English Country England, Great Britain
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
26334808
DOI
10.1093/jme/tjv023
Knihovny.cz E-resources
- MeSH
- Phylogeny MeSH
- Insect Proteins genetics metabolism MeSH
- Molecular Sequence Data MeSH
- Nymph genetics growth & development metabolism MeSH
- Panstrongylus genetics growth & development metabolism MeSH
- Proteomics MeSH
- Sialoglycoproteins genetics metabolism MeSH
- Salivary Proteins and Peptides genetics metabolism MeSH
- Saliva chemistry MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
Saliva of blood-sucking arthropods contains a complex cocktail of pharmacologically active compounds that assists feeding by counteracting their hosts' hemostatic and inflammatory reactions. Panstrongylus megistus (Burmeister) is an important vector of Chagas disease in South America, but despite its importance there is only one salivary protein sequence publicly deposited in GenBank. In the present work, we used Illumina technology to disclose and publicly deposit 3,703 coding sequences obtained from the assembly of >70 million reads. These sequences should assist proteomic experiments aimed at identifying pharmacologically active proteins and immunological markers of vector exposure. A supplemental file of the transcriptome and deducted protein sequences can be obtained from http://exon.niaid.nih.gov/transcriptome/P_megistus/Pmeg-web.xlsx.
References provided by Crossref.org
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