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The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
M. Delahaye-Sourdeix, J. Oliver, MN. Timofeeva, V. Gaborieau, M. Johansson, A. Chabrier, MB. Wozniak, DR. Brenner, MP. Vallée, D. Anantharaman, P. Lagiou, I. Holcátová, L. Richiardi, K. Kjaerheim, A. Agudo, X. Castellsagué, TV. Macfarlane, L....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural
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od 2006
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Public Library of Science (PLoS)
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- MeSH
- demografie MeSH
- DNA opravný a rekombinační protein Rad52 genetika MeSH
- fyzikální mapování chromozomů MeSH
- genetická predispozice k nemoci * MeSH
- genetické lokusy * MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 12 genetika MeSH
- lokus kvantitativního znaku genetika MeSH
- nádory hlavy a krku genetika MeSH
- nádory plic genetika MeSH
- počítačová simulace MeSH
- rizikové faktory MeSH
- spinocelulární karcinom genetika MeSH
- studie případů a kontrol MeSH
- zárodečné buňky MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
Biostatistics group Lyon France
Cancer Registry of Norway Oslo Norway
Catalan Institute of Oncology ICO IDIBELL L'Hospitalet de Llobregat Barcelona Spain
Centro di Riferimento Oncologico IRCSS Unit of Epidemiology and Biostatistics Aviano Italy
CIBER Epidemiología y Salud Pública Madrid Spain
Croatian National Cancer Registry Croatian National Institute of Public Health Zagreb Croatia
Department of Environmental Medicine and Public Health University of Padova Padova Italy
Department of Epidemiology Institute of Occupational Medicine Lodz Poland
Department of Health Promotion Division of Oral Pathology Kyushu Dental University Kitakyushu Japan
Dept of Molecular Oncology Cancer Institute Chennai Tamil Nadu India
Faculty of Mathematics and Computer Science University of Bremen Bremen Germany
General Hospital of Pordenone Pordenone Italy
Genetic Cancer Susceptibility group Lyon France
Genetic Epidemiology group Lyon France
Infections and Cancer Epidemiology group Lyon France
Institute of Carcinogenesis Cancer Research Centre Moscow Russian Federation
Institute of Oncology and Radiobiology Havana Cuba
International Prevention Research Institute Ecully France
Leibniz Institute for Prevention Research and Epidemiology BIPS Bremen Germany
National School of Public Health FIOCRUZ Rio de Janeiro Brazil
Palacky University Olomouc Czech Republic
Regional Authority of Public Health Banska Bystrica Slovakia
School of Medicine and Dentistry University of Aberdeen Aberdeen United Kingdom
The Tisch Cancer Institute Mount Sinai School of Medicine New York NY United States of America
Trinity College School of Dental Science Dublin Ireland
Universidade de Sao Paulo Sao Paulo Brazil
Universidade Federal de Pelotas Pelotas Brazil
University of Glasgow Dental School Glasgow Scotland United Kingdom
University of Manchester School of Dentistry Manchester United Kingdom
University of Turin Department of Medical Sciences Unit of Cancer Epidemiology Turin Italy
Citace poskytuje Crossref.org
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