Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Salicylanilide diethyl phosphates as potential inhibitors of some mycobacterial enzymes

M. Krátký, E. Novotná, S. Saxena, P. Yogeeswari, D. Sriram, M. Švarcová, J. Vinšová,

. 2014 ; 2014 (-) : 703053. [pub] 20141104

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16000425

Grant support
NT13346 MZ0 CEP Register

Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 µM and the best docking results. Other mycobacterial enzymes were mostly inhibited by some derivatives but at higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16000425
003      
CZ-PrNML
005      
20181212134152.0
007      
ta
008      
160108s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2014/703053 $2 doi
035    __
$a (PubMed)25538961
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Krátký, Martin $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. $7 jo2017947786
245    10
$a Salicylanilide diethyl phosphates as potential inhibitors of some mycobacterial enzymes / $c M. Krátký, E. Novotná, S. Saxena, P. Yogeeswari, D. Sriram, M. Švarcová, J. Vinšová,
520    9_
$a Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 µM and the best docking results. Other mycobacterial enzymes were mostly inhibited by some derivatives but at higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates.
650    _2
$a antituberkulotika $x chemie $7 D000995
650    12
$a bakteriální proteiny $x antagonisté a inhibitory $x chemie $7 D001426
650    _2
$a inhibitory enzymů $x chemie $7 D004791
650    12
$a simulace molekulového dockingu $7 D062105
650    _2
$a Mycobacterium tuberculosis $x enzymologie $7 D009169
650    _2
$a salicylanilidy $x chemie $7 D012458
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Novotná, Eva $u Department of Biochemical Sciences, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
700    1_
$a Saxena, Shalini $u Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Hyderabad 500078, India.
700    1_
$a Yogeeswari, Perumal $u Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Hyderabad 500078, India.
700    1_
$a Sriram, Dharmarajan $u Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Hyderabad 500078, India.
700    1_
$a Švarcová, Markéta $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
700    1_
$a Vinšová, Jarmila, $u Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. $d 1951- $7 nlk19990073991
773    0_
$w MED00181094 $t TheScientificWorldJournal $x 1537-744X $g Roč. 2014, č. - (2014), s. 703053
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25538961 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160108 $b ABA008
991    __
$a 20181212134316 $b ABA008
999    __
$a ok $b bmc $g 1102706 $s 924631
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 2014 $c - $d 703053 $e 20141104 $i 1537-744X $m TheScientificWorldJournal $n ScientificWorldJournal $x MED00181094
GRA    __
$a NT13346 $p MZ0
LZP    __
$a Pubmed-20160108

Find record

Citation metrics

Logged in users only

Archiving options