• Je něco špatně v tomto záznamu ?

Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer

T. Kunická, R. Václavíková, V. Hlaváč, D. Vrána, V. Pecha, K. Rauš, M. Trnková, K. Kubáčková, M. Ambruš, L. Vodičková, P. Vodička, P. Souček,

. 2014 ; 9 (7) : e101740. [pub] 20140731

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16000681

Grantová podpora
NT13679 MZ0 CEP - Centrální evidence projektů

OBJECTIVES: ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients. METHODS: The distribution of twelve ABCC1 polymorphisms was assessed by direct sequencing in peripheral blood DNA (n = 540). RESULTS: Tumors from carriers of the wild type genotype in rs35623 or rs35628 exhibited significantly lower levels of ABCC1 transcript than those from carriers of the minor allele (p = 0.003 and p = 0.004, respectively). The ABCC1 transcript levels significantly increased in the order CT-GT>CC-GT>CC-GG for the predicted rs35626-rs4148351 diplotype. Chemotherapy-treated patients carrying the T allele in rs4148353 had longer disease-free survival than those with the GG genotype (p = 0.043). On the other hand, hormonal therapy-treated patients with the AA genotype in rs35628 had significantly longer disease-free survival than carriers of the G allele (p = 0.012). CONCLUSIONS: Taken together, our study shows that genetic variability in the nucleotide binding domain 1 has a significant impact on the ABCC1 transcript level in the target tissue and may modify survival of breast cancer patients.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16000681
003      
CZ-PrNML
005      
20190514131145.0
007      
ta
008      
160108s2014 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1371/journal.pone.0101740 $2 doi
035    __
$a (PubMed)25078270
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kunická, Tereza $u Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.
245    10
$a Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer / $c T. Kunická, R. Václavíková, V. Hlaváč, D. Vrána, V. Pecha, K. Rauš, M. Trnková, K. Kubáčková, M. Ambruš, L. Vodičková, P. Vodička, P. Souček,
520    9_
$a OBJECTIVES: ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with corresponding transcript levels in tissues and clinical phenotype of breast cancer patients. METHODS: The distribution of twelve ABCC1 polymorphisms was assessed by direct sequencing in peripheral blood DNA (n = 540). RESULTS: Tumors from carriers of the wild type genotype in rs35623 or rs35628 exhibited significantly lower levels of ABCC1 transcript than those from carriers of the minor allele (p = 0.003 and p = 0.004, respectively). The ABCC1 transcript levels significantly increased in the order CT-GT>CC-GT>CC-GG for the predicted rs35626-rs4148351 diplotype. Chemotherapy-treated patients carrying the T allele in rs4148353 had longer disease-free survival than those with the GG genotype (p = 0.043). On the other hand, hormonal therapy-treated patients with the AA genotype in rs35628 had significantly longer disease-free survival than carriers of the G allele (p = 0.012). CONCLUSIONS: Taken together, our study shows that genetic variability in the nucleotide binding domain 1 has a significant impact on the ABCC1 transcript level in the target tissue and may modify survival of breast cancer patients.
650    _2
$a senioři $7 D000368
650    _2
$a nádory prsu $x genetika $x patofyziologie $7 D001943
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a lidé středního věku $7 D008875
650    _2
$a proteiny spojené s mnohočetnou rezistencí k lékům $x genetika $x metabolismus $7 D027425
650    12
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a messenger RNA $x genetika $7 D012333
650    12
$a analýza přežití $7 D016019
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Václavíková, Radka $u Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic. $7 xx0142918
700    1_
$a Hlaváč, Viktor $u Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic. $7 xx0270481
700    1_
$a Vrána, David $u Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic; Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic. $7 xx0103187
700    1_
$a Pecha, Václav, $u Institute for the Care for Mother and Child, Prague, Czech Republic. $d 1948- $7 xx0103675
700    1_
$a Rauš, Karel $u Institute for the Care for Mother and Child, Prague, Czech Republic. $7 xx0128450
700    1_
$a Trnková, Markéta $u Biolab Praha, k.s., Prague, Czech Republic. $7 xx0158385
700    1_
$a Kubáčková, Kateřina $u Department of Oncology, Motol University Hospital, Prague, Czech Republic. $7 xx0083614
700    1_
$a Ambruš, Miloslav $u Department of Radiotherapy and Oncology, Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic. $7 gn_A_00005468
700    1_
$a Vodičková, Ludmila $u Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic; Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic. $7 xx0128157
700    1_
$a Vodička, Pavel $u Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. $7 xx0060269
700    1_
$a Souček, Pavel $u Department of Toxicogenomics, National Institute of Public Health, Prague, Czech Republic. $7 xx0060511
773    0_
$w MED00180950 $t PloS one $x 1932-6203 $g Roč. 9, č. 7 (2014), s. e101740
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25078270 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160108 $b ABA008
991    __
$a 20190514131249 $b ABA008
999    __
$a ok $b bmc $g 1102962 $s 924887
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 9 $c 7 $d e101740 $e 20140731 $i 1932-6203 $m PLoS One $n PLoS One $x MED00180950
GRA    __
$a NT13679 $p MZ0
LZP    __
$a Pubmed-20160108

Najít záznam

Citační ukazatele

    Možnosti archivace