• Je něco špatně v tomto záznamu ?

A highly diverse spectrum of naphthoquinone derivatives produced by the endophytic fungus Biatriospora sp. CCF 4378

E. Stodůlková, P. Man, M. Kuzma, J. Černý, I. Císařová, A. Kubátová, M. Chudíčková, M. Kolařík, M. Flieger,

. 2015 ; 60 (3) : 259-67. [pub] 20141122

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16003190

A strain of Biatriospora sp. CCF 4378 was tested for the production of secondary metabolites under submerged fermentation conditions. Eleven compounds were isolated from the culture broth, and the structures of these compounds were determined using HRMS, NMR and X-ray analysis. In addition to six known naphthoquinone derivatives, i.e. ascomycone A, ascomycone B, 6-deoxyfusarubine, 6-deoxyanhydrofusarubine, herbarine and balticol A, one derivative of 2-azaanthraquinone, 6-deoxybostrycoidine, was also identified. Four new natural pyranonaphthoquinones were found, and these natural products were pleorubrin A, pleorubrin B, pleorubrin C and pleorubrin D. The toxicity on human cell lines of the crude naphthoquinone fraction and pure 6-deoxybostrycoidin, ascomycone B, pleorubrin B and 6-deoxyfusarubin was tested. Ascomycone B and 6-deoxyfusarubin elicited rapid cytotoxicity at micromolar concentrations.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16003190
003      
CZ-PrNML
005      
20160129121634.0
007      
ta
008      
160128s2015 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s12223-014-0366-7 $2 doi
035    __
$a (PubMed)25416512
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Stodůlková, Eva $u Institute of Microbiology of the ASCR, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czech Republic.
245    12
$a A highly diverse spectrum of naphthoquinone derivatives produced by the endophytic fungus Biatriospora sp. CCF 4378 / $c E. Stodůlková, P. Man, M. Kuzma, J. Černý, I. Císařová, A. Kubátová, M. Chudíčková, M. Kolařík, M. Flieger,
520    9_
$a A strain of Biatriospora sp. CCF 4378 was tested for the production of secondary metabolites under submerged fermentation conditions. Eleven compounds were isolated from the culture broth, and the structures of these compounds were determined using HRMS, NMR and X-ray analysis. In addition to six known naphthoquinone derivatives, i.e. ascomycone A, ascomycone B, 6-deoxyfusarubine, 6-deoxyanhydrofusarubine, herbarine and balticol A, one derivative of 2-azaanthraquinone, 6-deoxybostrycoidine, was also identified. Four new natural pyranonaphthoquinones were found, and these natural products were pleorubrin A, pleorubrin B, pleorubrin C and pleorubrin D. The toxicity on human cell lines of the crude naphthoquinone fraction and pure 6-deoxybostrycoidin, ascomycone B, pleorubrin B and 6-deoxyfusarubin was tested. Ascomycone B and 6-deoxyfusarubin elicited rapid cytotoxicity at micromolar concentrations.
650    _2
$a Ascomycota $x klasifikace $x genetika $x izolace a purifikace $x metabolismus $7 D001203
650    _2
$a buněčné linie $7 D002460
650    _2
$a viabilita buněk $x účinky léků $7 D002470
650    _2
$a endofyty $x klasifikace $x genetika $x izolace a purifikace $x metabolismus $7 D060026
650    _2
$a lidé $7 D006801
650    _2
$a molekulární struktura $7 D015394
650    _2
$a naftochinony $x chemie $x metabolismus $x farmakologie $7 D009285
650    _2
$a Ulmus $x mikrobiologie $7 D034403
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Man, Petr
700    1_
$a Kuzma, Marek
700    1_
$a Černý, Jan
700    1_
$a Císařová, Ivana
700    1_
$a Kubátová, Alena
700    1_
$a Chudíčková, Milada
700    1_
$a Kolařík, Miroslav
700    1_
$a Flieger, Miroslav
773    0_
$w MED00011005 $t Folia microbiologica $x 1874-9356 $g Roč. 60, č. 3 (2015), s. 259-67
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25416512 $y Pubmed
910    __
$a ABA008 $b online $c sign $y a $z 0
990    __
$a 20160128 $b ABA008
991    __
$a 20160129121801 $b ABA008
999    __
$a ok $b bmc $g 1105654 $s 927436
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 60 $c 3 $d 259-67 $e 20141122 $i 1874-9356 $m Folia microbiologica $n Folia microbiol. (Prague) $x MED00011005
LZP    __
$a Pubmed-20160128

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace