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Molecular Targeting of Human Papillomavirus oncogene expression using RNA interference Technology

Sarmistha Sen Raychaudhuri, Sreejata Raychaudhuri

. 2015 ; 2 (2) : 6-10.

Language English Country Czech Republic

Document type Review

Persistent link   https://www.medvik.cz/link/bmc16016274

Cervical cancer is a killer disease that claims innumerable lives of women all over the world. Human Papilloma Virus (HPV) serotypes 16 and 18 have been implicated as the causal organism of the disease. Initiation of sexual intercourse at an early age, multiple sex partners, poor hygiene etc are regarded as risk factors that are also associated with progression of HPV infection. Two genes in HPV encode the oncoproteins E6 and E7. These proteins have been found to be in high content in cervical cancer positive cell lines. Attempts have been made to selectively inhibit the expression of these two oncogenes by molecular biological techniques. Of these RNA interference (RNAi) deserves special mention. RNAi occurs naturally in mammalian cells through which expression of a particular gene can be knocked down with high precision. Different authors from time to time have targeted to knock out these E6 and E7 proteins as a preventive measure of cervical cancer. The present review portrays the state of the art evaluation of retrospective as well as recent literature on these challenging techniques.

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$a Cervical cancer is a killer disease that claims innumerable lives of women all over the world. Human Papilloma Virus (HPV) serotypes 16 and 18 have been implicated as the causal organism of the disease. Initiation of sexual intercourse at an early age, multiple sex partners, poor hygiene etc are regarded as risk factors that are also associated with progression of HPV infection. Two genes in HPV encode the oncoproteins E6 and E7. These proteins have been found to be in high content in cervical cancer positive cell lines. Attempts have been made to selectively inhibit the expression of these two oncogenes by molecular biological techniques. Of these RNA interference (RNAi) deserves special mention. RNAi occurs naturally in mammalian cells through which expression of a particular gene can be knocked down with high precision. Different authors from time to time have targeted to knock out these E6 and E7 proteins as a preventive measure of cervical cancer. The present review portrays the state of the art evaluation of retrospective as well as recent literature on these challenging techniques.
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