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Prognostic Significance of Serum and Urinary Neopterin Concentrations in Patients with Rectal Carcinoma Treated with Chemoradiation

M. Zezulová, M. Bartoušková, E. Hlídková, J. Juráňová, B. Červinková, E. Kasalová, T. Adam, LK. Krčmová, D. Solichová, K. Cwiertka, D. Vrána, B. Melichar,

. 2016 ; 36 (1) : 287-92.

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16020060

AIM: To analyze the prognostic significance of serum and urinary neopterin concentrations in patients with rectal adenocarcinoma treated with (chemo)radiation. PATIENTS AND METHODS: Urinary and serum neopterin and peripheral blood cell count were determined in 49 patients with rectal carcinoma before the start of (chemo)radiation. RESULTS: Neopterin concentrations exhibited a significant inverse correlation with hemoglobin and positive correlation with leukocyte count, platelet count and platelet-to-lymphocyte ratio. Increased serum neopterin concentration was associated with significantly inferior relapse-free survival (RFS) and overall survival. However, a significant association was observed only in 28 patients treated in the neoadjuvant setting. Although increased urinary neopterin was also associated with inferior RFS and overall survival, this was not statistically significant. The neutrophil-to-lymphocyte ratio was also associated with poor prognosis. CONCLUSION: The data presented herein indicate a prognostic significance of serum neopterin concentrations in patients with rectal cancer treated with neoadjuvant chemoradiation.

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$a AIM: To analyze the prognostic significance of serum and urinary neopterin concentrations in patients with rectal adenocarcinoma treated with (chemo)radiation. PATIENTS AND METHODS: Urinary and serum neopterin and peripheral blood cell count were determined in 49 patients with rectal carcinoma before the start of (chemo)radiation. RESULTS: Neopterin concentrations exhibited a significant inverse correlation with hemoglobin and positive correlation with leukocyte count, platelet count and platelet-to-lymphocyte ratio. Increased serum neopterin concentration was associated with significantly inferior relapse-free survival (RFS) and overall survival. However, a significant association was observed only in 28 patients treated in the neoadjuvant setting. Although increased urinary neopterin was also associated with inferior RFS and overall survival, this was not statistically significant. The neutrophil-to-lymphocyte ratio was also associated with poor prognosis. CONCLUSION: The data presented herein indicate a prognostic significance of serum neopterin concentrations in patients with rectal cancer treated with neoadjuvant chemoradiation.
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$a Bartoušková, Marie $u Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
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$a Hlídková, Eva $u Department of Clinical Biochemistry, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
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$a Juráňová, Jarmila $u Department of Hemato-Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
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$a Kasalová, Eva $u Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic. $7 xx0209611
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$a Krčmová Kujovská, Lenka, $u Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic. $d 1981- $7 xx0209338
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$a Solichová, Dagmar $u Third Department of Medicine, Charles University Teaching Hospital, Hradec Králové, Czech Republic.
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$a Cwiertka, Karel $u Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.
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$a Vrána, David $u Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic davvrana@gmail.com.
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