• Je něco špatně v tomto záznamu ?

Prognostic impact of neutrophil gelatinase-associated lipocalin and B-type natriuretic in patients with ST-elevation myocardial infarction treated by primary PCI: a prospective observational cohort study

K. Helanova, S. Littnerova, P. Kubena, E. Ganovska, M. Pavlusova, L. Kubkova, J. Jarkovsky, M. Pavkova Goldbergova, J. Lipkova, J. Gottwaldova, P. Kala, O. Toman, M. Dastych, J. Spinar, J. Parenica,

. 2015 ; 5 (10) : e006872. [pub] 20151005

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16020239

OBJECTIVES: Neutrophil gelatinase-associated lipocalin (NGAL) from a pathophysiological perspective connects various pathways that affect the prognosis after myocardial infarction. The objective was to evaluate the benefits of measuring NGAL for prognostic stratification in addition to the Thrombolysis in Myocardial Infarction (TIMI) score, and to compare it with the prognostic value of B-type natriuretic peptide (BNP). DESIGN: Prospective observational cohort study. SETTING: One university/tertiary centre. PARTICIPANTS: A total of 673 patients with ST segment elevation myocardial infarction were treated by primary percutaneous coronary intervention. NGAL and BNP were assessed on hospital admission. OUTCOMES: PRIMARY OUTCOME: 1-year mortality. SECONDARY OUTCOMES: 1-year hospitalisation due to acute heart failure, unplanned revascularisation, reinfarction, stroke and combined end point of 1-year mortality and hospitalisation due to heart failure. STATISTICAL METHODS: Using the c-statistic, the ability of NGAL, BNP and TIMI score to predict 1-year mortality alone and in combination with readmission for heart failure was evaluated. The addition of the predictive value of biomarkers to the score was assessed by category free net reclassification improvement (cfNRI) and the integrated discrimination index (IDI). RESULTS: The NGAL level was significantly higher in non-survivors (67 vs 115 pg/mL; p<0.001). The area under the curve (AUC) values for mortality prediction for NGAL, BNP and TIMI score were 75.5, 78.7 and 74.4, respectively (all p<0.001) with optimal cut-off values of 84 pg/mL for NGAL and 150 pg/mL for BNP. The addition of NGAL and BNP to the TIMI score significantly improved risk stratification according to cfNRI and IDI. A BNP and the combination of the TIMI score with NGAL predicted the occurrence of the combined end point with an AUC of 80.6 or 82.2, respectively. NGAL alone is a simple tool to identify very high-risk patients. NGAL >110 pg/mL was associated with a 1-year mortality of 20%. CONCLUSIONS: The measurement of NGAL together with the TIMI score results in a strong prognostic model for the 1-year mortality rate in patients with STEMI.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16020239
003      
CZ-PrNML
005      
20160726095701.0
007      
ta
008      
160722s2015 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1136/bmjopen-2014-006872 $2 doi
024    7_
$a 10.1136/bmjopen-2014-006872 $2 doi
035    __
$a (PubMed)26438132
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Helanova, Katerina $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic.
245    10
$a Prognostic impact of neutrophil gelatinase-associated lipocalin and B-type natriuretic in patients with ST-elevation myocardial infarction treated by primary PCI: a prospective observational cohort study / $c K. Helanova, S. Littnerova, P. Kubena, E. Ganovska, M. Pavlusova, L. Kubkova, J. Jarkovsky, M. Pavkova Goldbergova, J. Lipkova, J. Gottwaldova, P. Kala, O. Toman, M. Dastych, J. Spinar, J. Parenica,
520    9_
$a OBJECTIVES: Neutrophil gelatinase-associated lipocalin (NGAL) from a pathophysiological perspective connects various pathways that affect the prognosis after myocardial infarction. The objective was to evaluate the benefits of measuring NGAL for prognostic stratification in addition to the Thrombolysis in Myocardial Infarction (TIMI) score, and to compare it with the prognostic value of B-type natriuretic peptide (BNP). DESIGN: Prospective observational cohort study. SETTING: One university/tertiary centre. PARTICIPANTS: A total of 673 patients with ST segment elevation myocardial infarction were treated by primary percutaneous coronary intervention. NGAL and BNP were assessed on hospital admission. OUTCOMES: PRIMARY OUTCOME: 1-year mortality. SECONDARY OUTCOMES: 1-year hospitalisation due to acute heart failure, unplanned revascularisation, reinfarction, stroke and combined end point of 1-year mortality and hospitalisation due to heart failure. STATISTICAL METHODS: Using the c-statistic, the ability of NGAL, BNP and TIMI score to predict 1-year mortality alone and in combination with readmission for heart failure was evaluated. The addition of the predictive value of biomarkers to the score was assessed by category free net reclassification improvement (cfNRI) and the integrated discrimination index (IDI). RESULTS: The NGAL level was significantly higher in non-survivors (67 vs 115 pg/mL; p<0.001). The area under the curve (AUC) values for mortality prediction for NGAL, BNP and TIMI score were 75.5, 78.7 and 74.4, respectively (all p<0.001) with optimal cut-off values of 84 pg/mL for NGAL and 150 pg/mL for BNP. The addition of NGAL and BNP to the TIMI score significantly improved risk stratification according to cfNRI and IDI. A BNP and the combination of the TIMI score with NGAL predicted the occurrence of the combined end point with an AUC of 80.6 or 82.2, respectively. NGAL alone is a simple tool to identify very high-risk patients. NGAL >110 pg/mL was associated with a 1-year mortality of 20%. CONCLUSIONS: The measurement of NGAL together with the TIMI score results in a strong prognostic model for the 1-year mortality rate in patients with STEMI.
650    _2
$a proteiny akutní fáze $7 D000209
650    _2
$a biologické markery $x krev $7 D015415
650    12
$a elektrokardiografie $7 D004562
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    _2
$a lipokaliny $x krev $7 D054834
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a infarkt myokardu $x krev $x diagnóza $x mortalita $7 D009203
650    _2
$a natriuretický peptid typu B $x krev $7 D020097
650    12
$a koronární angioplastika $7 D062645
650    _2
$a pooperační období $7 D011184
650    _2
$a prognóza $7 D011379
650    _2
$a prospektivní studie $7 D011446
650    _2
$a protoonkogenní proteiny $x krev $7 D011518
650    _2
$a ROC křivka $7 D012372
650    _2
$a míra přežití $x trendy $7 D015996
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Littnerova, Simona $u Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
700    1_
$a Kubena, Petr $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic.
700    1_
$a Ganovska, Eva $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic.
700    1_
$a Pavlusova, Marie $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic.
700    1_
$a Kubkova, Lenka $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic.
700    1_
$a Jarkovsky, Jiri $u Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.
700    1_
$a Pavkova Goldbergova, Monika $u Faculty of Medicine, Institute of Pathological Physiology, Masaryk University, Brno, Czech Republic.
700    1_
$a Lipkova, Jolana $u Faculty of Medicine, Institute of Pathological Physiology, Masaryk University, Brno, Czech Republic.
700    1_
$a Gottwaldova, Jana $u Department of Biochemistry, University Hospital Brno, Brno, Czech Republic Faculty of Medicine, Department of Laboratory Methods, Masaryk University, Brno, Czech Republic.
700    1_
$a Kala, Petr $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic.
700    1_
$a Toman, Ondrej $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic Department of Cardiovascular Disease, International Clinical Research Center -University Hospital St Anne's, Brno, Czech Republic.
700    1_
$a Dastych, Milan $u Department of Biochemistry, University Hospital Brno, Brno, Czech Republic Faculty of Medicine, Department of Laboratory Methods, Masaryk University, Brno, Czech Republic.
700    1_
$a Spinar, Jindrich $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic Department of Cardiovascular Disease, International Clinical Research Center -University Hospital St Anne's, Brno, Czech Republic.
700    1_
$a Parenica, Jiri $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic Medical Faculty, Masaryk University, Brno, Czech Republic Department of Cardiovascular Disease, International Clinical Research Center -University Hospital St Anne's, Brno, Czech Republic.
773    0_
$w MED00184484 $t BMJ open $x 2044-6055 $g Roč. 5, č. 10 (2015), s. e006872
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26438132 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160722 $b ABA008
991    __
$a 20160726095920 $b ABA008
999    __
$a ok $b bmc $g 1154909 $s 944767
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 5 $c 10 $d e006872 $e 20151005 $i 2044-6055 $m BMJ open $n BMJ Open $x MED00184484
LZP    __
$a Pubmed-20160722

Najít záznam

Citační ukazatele

Možnosti archivace