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Regadenoson-Stress Dynamic Myocardial Perfusion Improves Diagnostic Performance of CT Angiography in Assessment of Intermediate Coronary Artery Stenosis in Asymptomatic Patients

J. Baxa, M. Hromádka, J. Šedivý, L. Štěpánková, J. Moláček, B. Schmidt, T. Flohr, J. Ferda,

. 2015 ; 2015 (-) : 105629. [pub] 20150705

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16020451

The prospective study included 54 asymptomatic high-risk patients who underwent coronary CT angiography (CTA) and regadenoson-induced stress CT perfusion (rsCTP). Diagnostic accuracy of significant stenosis (≥50%) determination was evaluated for CTA alone and CTA + rsCTP in 27 patients referred to ICA due to the positive rsCTP findings. Combined evaluation of CTA + rsCTP had higher diagnostic accuracy over CTA alone (per-segment: specificity 96 versus 68%, p = 0.002; per-vessel: specificity 95 versus 75%, p = 0.012) and high overruling rate of rsCTP was proved in intermediate stenosis (40-70%). Results demonstrate a significant additional value of rsCTP in the assessment of intermediate coronary artery stenosis found with CTA.

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$a Hromádka, Milan $u Department of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
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$a Šedivý, Jakub $u Department of Cardiology, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
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$a Štěpánková, Lucie $u Department of Internal Medicine, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
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$a Moláček, Jiří $u Department of Surgery, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
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$a Schmidt, Bernhard $u Siemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, Germany.
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$a Flohr, Thomas $u Siemens Healthcare, CT Physics and Applications Development, Siemensstrasse 1, 91301 Forchheim, Germany.
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$a Ferda, Jiří $u Department of Imaging Methods, University Hospital Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
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