• Something wrong with this record ?

Increased levels of soluble ST2 in patients with active newly diagnosed ANCA-associated vasculitis

Z. Hladinova, Z. Hruskova, B. Svobodova, K. Malickova, V. Lanska, P. Konopásek, E. Jancova, R. Rysava, CL. Edelstein, V. Tesar,

. 2015 ; 2015 (-) : 603750. [pub] 20150223

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16020926

OBJECTIVE: ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV). METHODS: 139 AAV patients and 62 controls were studied. IL-33 and sST2 in the blood were measured with a commercially available ELISA. RESULTS: Newly diagnosed AAV patients had higher sST2 levels than controls (P < 0.01). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (P < 0.001). IL-33 levels were higher in AAV patients than in the control groups (P = 0.002). However, serum IL-33 levels were not increased in patients with active AAV compared to patients in remission. IL-33 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (P = 0.012). CONCLUSIONS: Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16020926
003      
CZ-PrNML
005      
20160727122040.0
007      
ta
008      
160722s2015 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1155/2015/603750 $2 doi
024    7_
$a 10.1155/2015/603750 $2 doi
035    __
$a (PubMed)25802482
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hladinova, Z $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
245    10
$a Increased levels of soluble ST2 in patients with active newly diagnosed ANCA-associated vasculitis / $c Z. Hladinova, Z. Hruskova, B. Svobodova, K. Malickova, V. Lanska, P. Konopásek, E. Jancova, R. Rysava, CL. Edelstein, V. Tesar,
520    9_
$a OBJECTIVE: ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV). METHODS: 139 AAV patients and 62 controls were studied. IL-33 and sST2 in the blood were measured with a commercially available ELISA. RESULTS: Newly diagnosed AAV patients had higher sST2 levels than controls (P < 0.01). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (P < 0.001). IL-33 levels were higher in AAV patients than in the control groups (P = 0.002). However, serum IL-33 levels were not increased in patients with active AAV compared to patients in remission. IL-33 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (P = 0.012). CONCLUSIONS: Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a ANCA-asociované vaskulitidy $x imunologie $7 D056648
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a interleukin 33 $x krev $7 D000067596
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a receptory buněčného povrchu $x krev $7 D011956
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Hruskova, Z $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic ; Institute of Immunology and Microbiology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
700    1_
$a Svobodova, B $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
700    1_
$a Malickova, K $u Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
700    1_
$a Lanska, V $u Statistical Unit, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
700    1_
$a Konopásek, P $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
700    1_
$a Jancova, E $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
700    1_
$a Rysava, R $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
700    1_
$a Edelstein, C L $u Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 800 45, USA.
700    1_
$a Tesar, V $u Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
773    0_
$w MED00006378 $t Mediators of inflammation $x 1466-1861 $g Roč. 2015, č. - (2015), s. 603750
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25802482 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160722 $b ABA008
991    __
$a 20160727122301 $b ABA008
999    __
$a ok $b bmc $g 1155596 $s 945454
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 2015 $c - $d 603750 $e 20150223 $i 1466-1861 $m Mediators of inflammation $n Mediators Inflamm $x MED00006378
LZP    __
$a Pubmed-20160722

Find record

Citation metrics

    Archiving options