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A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study
AC. Rawstron, C. Fazi, A. Agathangelidis, N. Villamor, R. Letestu, J. Nomdedeu, C. Palacio, O. Stehlikova, KA. Kreuzer, S. Liptrot, D. O'Brien, RM. de Tute, I. Marinov, M. Hauwel, M. Spacek, J. Dobber, AP. Kater, P. Gambell, A. Soosapilla, G....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Open Access Digital Library od 1997-01-01
Nursing & Allied Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
Odkazy
PubMed
26639181
DOI
10.1038/leu.2015.313
Knihovny.cz E-zdroje
- MeSH
- CD antigeny metabolismus MeSH
- chronická lymfatická leukemie patologie terapie MeSH
- dospělí MeSH
- imunofenotypizace MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- následné studie MeSH
- prognóza MeSH
- průtoková cytometrie normy MeSH
- reziduální nádor diagnóza genetika metabolismus MeSH
- staging nádorů MeSH
- vysoce účinné nukleotidové sekvenování metody MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
In chronic lymphocytic leukemia (CLL) the level of minimal residual disease (MRD) after therapy is an independent predictor of outcome. Given the increasing number of new agents being explored for CLL therapy, using MRD as a surrogate could greatly reduce the time necessary to assess their efficacy. In this European Research Initiative on CLL (ERIC) project we have identified and validated a flow-cytometric approach to reliably quantitate CLL cells to the level of 0.0010% (10(-5)). The assay comprises a core panel of six markers (i.e. CD19, CD20, CD5, CD43, CD79b and CD81) with a component specification independent of instrument and reagents, which can be locally re-validated using normal peripheral blood. This method is directly comparable to previous ERIC-designed assays and also provides a backbone for investigation of new markers. A parallel analysis of high-throughput sequencing using the ClonoSEQ assay showed good concordance with flow cytometry results at the 0.010% (10(-4)) level, the MRD threshold defined in the 2008 International Workshop on CLL guidelines, but it also provides good linearity to a detection limit of 1 in a million (10(-6)). The combination of both technologies would permit a highly sensitive approach to MRD detection while providing a reproducible and broadly accessible method to quantify residual disease and optimize treatment in CLL.
3rd Medical Department Paracelsus Medical University Salzburg Austria
Adaptive Biotechnologies Seattle WA USA
Department of Haematology Royal North Shore Hospital Sydney Australia
Department of Hematology Academic Medical Centre Amsterdam Netherlands
Divisions of Hematology and Hematopathology Mayo Clinic Rochester MN USA
General University Hospital Prague Czech Republic
Hematology and Flow Cytometry Laverty Pathology Sydney Australia
HMDS St James's Institute of Oncology Leeds UK
Hôpital Avicenne Assistance Publique Hôpitaux de Paris Bobigny France
Hospital Clínic IDIBAPS Barcelona Spain
Hospital de la Santa Creu i Sant Pau Barcelona Spain
Hospital Universitari Vall d'Hebron Barcelona Spain
Institute of Hematology and Blood Transfusion University Hospital Prague Prague Czech Republic
IRCCS San Raffaele Scientific Institute Milano Italy
IRCCS San Raffaele Scientific Institute Milano Italy Università Vita Salute San Raffaele Milan Italy
Leeds Institute of Cancer and Pathology University of Leeds Leeds UK
MD Anderson Cancer Center Houston TX USA
Moores Cancer Center University of California San Diego La Jolla CA USA
National Cancer Institute National Institutes of Health Bethesda MD USA
Ohio State University Medical Center Columbus OH USA
Peter MacCallum Cancer Centre Melbourne Australia
Royal Liverpool and Broadgreen University Hospitals NHS Trust Liverpool UK
St James Hospital Dublin Ireland
Un1iversity of Pittsburgh Pittsburgh PA USA
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