-
Je něco špatně v tomto záznamu ?
Early-onset and very-early-onset bipolar disorder: distinct or similar clinical conditions
L. Propper, A. Ortiz, C. Slaney, J. Garnham, M. Ruzickova, CV. Calkin, C. O'Donovan, T. Hajek, M. Alda,
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26576693
DOI
10.1111/bdi.12346
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha * diagnóza epidemiologie psychologie MeSH
- depresivní porucha unipolární diagnóza epidemiologie psychologie MeSH
- dospělí MeSH
- hyperkinetická porucha * diagnóza epidemiologie psychologie MeSH
- komorbidita MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- poruchy nálady diagnóza epidemiologie psychologie MeSH
- psychiatrické posuzovací škály MeSH
- psychopatologie MeSH
- rodina psychologie MeSH
- věk při počátku nemoci MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Kanada MeSH
OBJECTIVE: This study aimed to examine differences in the clinical presentation of very-early-onset (VEO) and early-onset (EO) bipolar disorder (BD) not fully explored previously. METHODS: We selected two groups of subjects with BD from the Maritime Bipolar Registry based on age at onset of first major mood episode (VEO with onset prior to age 15 years; EO ranging from 15 to 18 years) and compared them with a reference group (onset after 18 years of age). There were 363 subjects (240 with bipolar I disorder and 123 with bipolar II disorder; mean age 44.2 ± 12.8 (SD) years), with 41 subjects in the VEO and 95 in the EO groups. RESULTS: In comparison with the EO and reference groups, more subjects in the VEO group developed major depression as an index episode (88% for the VEO group versus 61% for the EO group and 54% for the reference group), and had an unremitting clinical course (65% versus 42% and 42%, respectively), rapid cycling (54% versus 34% and 28%, respectively), and comorbid attention-deficit hyperactivity disorder (17% versus 1% and 3%, respectively); a higher proportion of the VEO group had first-degree relatives with affective disorders compared with the EO and reference groups (0.41 versus 0.32 and 0.29, respectively), and they had lower scores on the Global Assessment of Functioning scale (mean scores of 64 versus 70 and 70). Overall, the EO group was similar to the reference group on most measures, except for increased suicidal behavior VEO 53%, EO 44% and reference group 25%). The results of polychotomous logistic regression also support the view that VEO BD represents a rather specific subtype of BD. CONCLUSIONS: Our results suggest the recognized correlates of early-onset BD may be driven by subjects at the lowest end of the age at onset spectrum.
Capital Health Addictions and Mental Health Program Halifax NS Canada
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Queens University Kingston ON Canada
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16027951
- 003
- CZ-PrNML
- 005
- 20161006120653.0
- 007
- ta
- 008
- 161005s2015 dk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/bdi.12346 $2 doi
- 024 7_
- $a 10.1111/bdi.12346 $2 doi
- 035 __
- $a (PubMed)26576693
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a dk
- 100 1_
- $a Propper, Lukas $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 245 10
- $a Early-onset and very-early-onset bipolar disorder: distinct or similar clinical conditions / $c L. Propper, A. Ortiz, C. Slaney, J. Garnham, M. Ruzickova, CV. Calkin, C. O'Donovan, T. Hajek, M. Alda,
- 520 9_
- $a OBJECTIVE: This study aimed to examine differences in the clinical presentation of very-early-onset (VEO) and early-onset (EO) bipolar disorder (BD) not fully explored previously. METHODS: We selected two groups of subjects with BD from the Maritime Bipolar Registry based on age at onset of first major mood episode (VEO with onset prior to age 15 years; EO ranging from 15 to 18 years) and compared them with a reference group (onset after 18 years of age). There were 363 subjects (240 with bipolar I disorder and 123 with bipolar II disorder; mean age 44.2 ± 12.8 (SD) years), with 41 subjects in the VEO and 95 in the EO groups. RESULTS: In comparison with the EO and reference groups, more subjects in the VEO group developed major depression as an index episode (88% for the VEO group versus 61% for the EO group and 54% for the reference group), and had an unremitting clinical course (65% versus 42% and 42%, respectively), rapid cycling (54% versus 34% and 28%, respectively), and comorbid attention-deficit hyperactivity disorder (17% versus 1% and 3%, respectively); a higher proportion of the VEO group had first-degree relatives with affective disorders compared with the EO and reference groups (0.41 versus 0.32 and 0.29, respectively), and they had lower scores on the Global Assessment of Functioning scale (mean scores of 64 versus 70 and 70). Overall, the EO group was similar to the reference group on most measures, except for increased suicidal behavior VEO 53%, EO 44% and reference group 25%). The results of polychotomous logistic regression also support the view that VEO BD represents a rather specific subtype of BD. CONCLUSIONS: Our results suggest the recognized correlates of early-onset BD may be driven by subjects at the lowest end of the age at onset spectrum.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a věk při počátku nemoci $7 D017668
- 650 12
- $a hyperkinetická porucha $x diagnóza $x epidemiologie $x psychologie $7 D001289
- 650 12
- $a bipolární porucha $x diagnóza $x epidemiologie $x psychologie $7 D001714
- 650 _2
- $a komorbidita $7 D015897
- 650 _2
- $a depresivní porucha unipolární $x diagnóza $x epidemiologie $x psychologie $7 D003865
- 650 _2
- $a rodina $x psychologie $7 D005190
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a poruchy nálady $x diagnóza $x epidemiologie $x psychologie $7 D019964
- 650 _2
- $a psychiatrické posuzovací škály $7 D011569
- 650 _2
- $a psychopatologie $7 D011599
- 651 _2
- $a Kanada $x epidemiologie $7 D002170
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Ortiz, Abigail $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a Slaney, Claire $u Capital Health Addictions and Mental Health Program, Halifax, NS, Canada.
- 700 1_
- $a Garnham, Julie $u Capital Health Addictions and Mental Health Program, Halifax, NS, Canada.
- 700 1_
- $a Ruzickova, Martina $u Department of Psychiatry, Queens University, Kingston, ON, Canada.
- 700 1_
- $a Calkin, Cynthia V $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a O'Donovan, Claire $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a Hajek, Tomas $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Alda, Martin $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. National Institute of Mental Health, Klecany, Czech Republic. $7 xx0072985
- 773 0_
- $w MED00007648 $t Bipolar disorders $x 1399-5618 $g Roč. 17, č. 8 (2015), s. 814-20
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26576693 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20161005 $b ABA008
- 991 __
- $a 20161006121042 $b ABA008
- 999 __
- $a ok $b bmc $g 1166265 $s 952581
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 17 $c 8 $d 814-20 $e 20151118 $i 1399-5618 $m Bipolar disorders $n Bipolar Disord $x MED00007648
- LZP __
- $a Pubmed-20161005
